EPOR (erythropoietin receptor)

2003-12-01  

Identity

HGNC
EPOR
LOCATION
19p13.2
LOCUSID
2057
ALIAS
EPO-R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2057
MIM: 133171
HGNC: 3416
Ensembl: ENSG00000187266

Variants:

dbSNP: 2057
ClinVar: 2057
TCGA: ENSG00000187266
COSMIC: EPOR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187266ENST00000222139P19235
ENSG00000187266ENST00000586890K7EP50
ENSG00000187266ENST00000588859K7EN47
ENSG00000187266ENST00000591958K7ERB5
ENSG00000187266ENST00000592375P19235

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Hematopoietic cell lineageKEGGko04640
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Hematopoietic cell lineageKEGGhsa04640
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151

References

Pubmed IDYearTitleCitations
152052612004Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells.59
181582852008Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F.53
153586192005Both proteasomes and lysosomes degrade the activated erythropoietin receptor.52
258877762015Emerging EPO and EPO receptor regulators and signal transducers.44
172934802007Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice.42
201245132010Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells.41
180066992008Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders.37
241655692013miR-125b targets erythropoietin and its receptor and their expression correlates with metastatic potential and ERBB2/HER2 expression.35
208612492010Role of erythropoietin receptor signaling in parvovirus B19 replication in human erythroid progenitor cells.32
121180932002Functional significance of erythropoietin receptor expression in breast cancer.29

Citation

Dessen P

EPOR (erythropoietin receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40475/epor-(erythropoietin-receptor)