F2R (coagulation factor II thrombin receptor)

2003-06-01 Affiliation

Identity

HGNC

F2R

LOCATION

5q13.3

LOCUSID

2149

ALIAS

CF2R,HTR,PAR-1,PAR1,TR

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2149
MIM: 187930
HGNC: 3537
Ensembl: ENSG00000181104

Variants:

dbSNP: 2149
ClinVar: 2149
TCGA: ENSG00000181104
COSMIC: F2R

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000181104	ENST00000319211	P25116
ENSG00000181104	ENST00000319211	A0A024RAP7
ENSG00000181104	ENST00000505600	G3XAL6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Complement and coagulation cascades	KEGG	ko04610
Regulation of actin cytoskeleton	KEGG	ko04810
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Complement and coagulation cascades	KEGG	hsa04610
Regulation of actin cytoskeleton	KEGG	hsa04810
Pathways in cancer	KEGG	hsa05200
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Platelet activation	KEGG	hsa04611
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Thrombin signalling through proteinase activated receptors (PARs)	REACTOME	R-HSA-456926
Formation of Fibrin Clot (Clotting Cascade)	REACTOME	R-HSA-140877
Common Pathway of Fibrin Clot Formation	REACTOME	R-HSA-140875
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA157	F2	Gene	Pathway	associated	20938371
PA174	GNAQ	Gene	Pathway	associated	20938371
PA176	GNB3	Gene	Pathway	associated	20938371
PA28764	GNA11	Gene	Pathway	associated	20938371
PA28765	GNA12	Gene	Pathway	associated	20938371
PA28766	GNA13	Gene	Pathway	associated	20938371
PA28768	GNA15	Gene	Pathway	associated	20938371

References

Pubmed ID	Year	Title	Citations
15707890	2005	PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.	250
12052963	2002	Activation of endothelial cell protease activated receptor 1 by the protein C pathway.	247
21673343	2011	Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4.	209
15626732	2005	Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation.	166
23222541	2012	High-resolution crystal structure of human protease-activated receptor 1.	147
17823308	2007	The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells.	93
16952995	2006	Protease-activated receptors in cardiovascular diseases.	92
19379698	2009	Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site.	90
15878870	2005	Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.	87
11907122	2002	Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells.	86

Citation

Dessen P

F2R (coagulation factor II thrombin receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40521/f2r