RMDN3 (regulator of microtubule dynamics 3)

2003-12-01  

Identity

HGNC
RMDN3
LOCATION
15q15.1
LOCUSID
55177
ALIAS
FAM82A2,FAM82C,RMD-3,RMD3,ptpip51
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55177
MIM: 611873
HGNC: 25550
Ensembl: ENSG00000137824

Variants:

dbSNP: 55177
ClinVar: 55177
TCGA: ENSG00000137824
COSMIC: RMDN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137824ENST00000260385Q96TC7
ENSG00000137824ENST00000260385A0A024R9P6
ENSG00000137824ENST00000338376Q96TC7
ENSG00000137824ENST00000338376A0A024R9P6
ENSG00000137824ENST00000558232H0YMB1
ENSG00000137824ENST00000558777H0YLV7
ENSG00000137824ENST00000560460H0YNE5
ENSG00000137824ENST00000560905H0YLG5

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383959652024Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca(2+) and synaptic defects.1
383959652024Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca(2+) and synaptic defects.1
352401622022PTPIP51 inhibits non-small-cell lung cancer by promoting PTEN-mediated EGFR degradation.2
352401622022PTPIP51 inhibits non-small-cell lung cancer by promoting PTEN-mediated EGFR degradation.2
339381122021Phospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes.40
339381122021Phospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes.40
326829532020Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain.30
326829532020Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain.30
277341502017Orchestrating cellular signaling pathways-the cellular "conductor" protein tyrosine phosphatase interacting protein 51 (PTPIP51).7
281328112017The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy.200
277341502017Orchestrating cellular signaling pathways-the cellular "conductor" protein tyrosine phosphatase interacting protein 51 (PTPIP51).7
281328112017The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy.200
258620042015PTPIP51 levels in glioblastoma cells depend on inhibition of the EGF-receptor.6
258620042015PTPIP51 levels in glioblastoma cells depend on inhibition of the EGF-receptor.6
245017732014The known interactome of PTPIP51 in HaCaT cells—inhibition of kinases and receptors.9

Citation

Dessen P

RMDN3 (regulator of microtubule dynamics 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40586/case-report-explorer/css/lib/dataTables.bootstrap.min.css