FLT1 (fms related receptor tyrosine kinase 1)

2003-02-01  

Identity

HGNC
LOCATION
13q12.3
LOCUSID
ALIAS
FLT,FLT-1,VEGFR-1,VEGFR1
FUSION GENES

Other Information

Locus ID:

NCBI: 2321
MIM: 165070
HGNC: 3763
Ensembl: ENSG00000102755

Variants:

dbSNP: 2321
ClinVar: 2321
TCGA: ENSG00000102755
COSMIC: FLT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102755ENST00000282397P17948
ENSG00000102755ENST00000282397L7RSL3
ENSG00000102755ENST00000539099P17948
ENSG00000102755ENST00000540678H9N1E8
ENSG00000102755ENST00000541932P17948
ENSG00000102755ENST00000543394P17948
ENSG00000102755ENST00000615611H9N1E7
ENSG00000102755ENST00000615840P17948
ENSG00000102755ENST00000617835H9N1E8
ENSG00000102755ENST00000639477A0A1W2PNW4

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Focal adhesionKEGGko04510
Cytokine-cytokine receptor interactionKEGGhsa04060
Focal adhesionKEGGhsa04510
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGF ligand-receptor interactionsREACTOMER-HSA-194313
VEGF binds to VEGFR leading to receptor dimerizationREACTOMER-HSA-195399
Neurophilin interactions with VEGF and VEGFRREACTOMER-HSA-194306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162372840sunitinibChemicalMultilinkAnnotation, Pathway, VariantAnnotationassociatedPD19248971, 20124951, 26935927
PA164924493axitinibChemicalPathwayassociated20124951
PA166118340motesanibChemicalPathwayassociated20124951
PA166123207overall survivalDiseaseVariantAnnotationassociatedPD26935927
PA29444HRASGenePathwayassociated28362716
PA30196KRASGenePathwayassociated28362716
PA31768NRASGenePathwayassociated28362716
PA33304PIK3C2AGenePathwayassociated28362716
PA33305PIK3C2BGenePathwayassociated28362716
PA33308PIK3CAGenePathwayassociated28362716
PA33309PIK3CBGenePathwayassociated28362716
PA33310PIK3CDGenePathwayassociated28362716
PA33311PIK3CGGenePathwayassociated28362716
PA33312PIK3R1GenePathwayassociated28362716
PA33313PIK3R2GenePathwayassociated28362716
PA33314PIK3R3GenePathwayassociated28362716
PA37302VEGFAGenePathwayassociated20124951
PA37303VEGFBGenePathwayassociated20124951
PA37304VEGFCGenePathwayassociated20124951
PA443624Carcinoma, Renal CellDiseaseVariantAnnotationassociatedPD26935927
PA7000sorafenibChemicalPathwayassociated28362716

References

Pubmed IDYearTitleCitations
163410072005VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.890
181752412008A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate.187
231723032013Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases.180
154721152004Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia.150
197180252009Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.143
120918802002Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment.132
146028042003Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences.118
189316842008Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma.103
175503032007Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1.101
127279952003Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia.97

Citation

Dessen P

FLT1 (fms related receptor tyrosine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40610/flt1