FN1 (fibronectin 1)

2003-02-01 Affiliation

Identity

HGNC

FN1

LOCATION

2q35

LOCUSID

2335

ALIAS

CIG,ED-B,FINC,FN,FNZ,GFND,GFND2,LETS,MSF,SMDCF

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2335
MIM: 135600
HGNC: 3778
Ensembl: ENSG00000115414

Variants:

dbSNP: 2335
ClinVar: 2335
TCGA: ENSG00000115414
COSMIC: FN1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115414	ENST00000323926	P02751
ENSG00000115414	ENST00000336916	P02751
ENSG00000115414	ENST00000354785	P02751
ENSG00000115414	ENST00000356005	P02751
ENSG00000115414	ENST00000357867	P02751
ENSG00000115414	ENST00000359671	P02751
ENSG00000115414	ENST00000421182	P02751
ENSG00000115414	ENST00000426059	P02751
ENSG00000115414	ENST00000432072	P02751
ENSG00000115414	ENST00000438981	H0Y4K8
ENSG00000115414	ENST00000443816	P02751
ENSG00000115414	ENST00000446046	P02751
ENSG00000115414	ENST00000456923	H0Y7Z1

Expression (GTEx)

5000

10000

15000

20000

25000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Focal adhesion	KEGG	ko04510
ECM-receptor interaction	KEGG	ko04512
Regulation of actin cytoskeleton	KEGG	ko04810
Small cell lung cancer	KEGG	ko05222
Focal adhesion	KEGG	hsa04510
ECM-receptor interaction	KEGG	hsa04512
Regulation of actin cytoskeleton	KEGG	hsa04810
Pathways in cancer	KEGG	hsa05200
Small cell lung cancer	KEGG	hsa05222
Bacterial invasion of epithelial cells	KEGG	ko05100
Bacterial invasion of epithelial cells	KEGG	hsa05100
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
MAP2K and MAPK activation	REACTOME	R-HSA-5674135
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Platelet Aggregation (Plug Formation)	REACTOME	R-HSA-76009
Integrin alphaIIb beta3 signaling	REACTOME	R-HSA-354192
GRB2:SOS provides linkage to MAPK signaling for Integrins	REACTOME	R-HSA-354194
p130Cas linkage to MAPK signaling for integrins	REACTOME	R-HSA-372708
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Platelet degranulation	REACTOME	R-HSA-114608
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Extracellular matrix organization	REACTOME	R-HSA-1474244
Fibronectin matrix formation	REACTOME	R-HSA-1566977
Integrin cell surface interactions	REACTOME	R-HSA-216083
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
RET signaling	REACTOME	R-HSA-8853659
Oncogenic MAPK signaling	REACTOME	R-HSA-6802957
Signaling by RAS mutants	REACTOME	R-HSA-6802949
Signaling by high-kinase activity BRAF mutants	REACTOME	R-HSA-6802948
Signaling by moderate kinase activity BRAF mutants	REACTOME	R-HSA-6802946
Paradoxical activation of RAF signaling by kinase inactive BRAF	REACTOME	R-HSA-6802955
Signaling by BRAF and RAF fusions	REACTOME	R-HSA-6802952
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37525423	2024	Fibronectin sensitizes activation of contractility, YAP, and NF-κB in nucleus pulposus cells.	0
37957805	2024	LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.	0
38160601	2024	Single-cell RNA sequencing reveals association of aberrant placental trophoblasts and FN1 reduction in late-onset fetal growth restriction.	0
38216996	2024	Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.	0
38328983	2024	Superficial acral calcified chondroid mesenchymal neoplasm harboring an FN1::FGFR2 fusion and review of the literature.	0
38349126	2024	Myocardin regulates fibronectin expression and secretion from human pleural mesothelial cells.	0
38598053	2024	Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease.	2
37525423	2024	Fibronectin sensitizes activation of contractility, YAP, and NF-κB in nucleus pulposus cells.	0
37957805	2024	LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.	0
38160601	2024	Single-cell RNA sequencing reveals association of aberrant placental trophoblasts and FN1 reduction in late-onset fetal growth restriction.	0
38216996	2024	Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.	0
38328983	2024	Superficial acral calcified chondroid mesenchymal neoplasm harboring an FN1::FGFR2 fusion and review of the literature.	0
38349126	2024	Myocardin regulates fibronectin expression and secretion from human pleural mesothelial cells.	0
38598053	2024	Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease.	2
36278453	2023	FN1 Promotes Thyroid Carcinoma Cell Proliferation and Metastasis by Activating the NF-Κb Pathway.	3

Citation

Dessen P

FN1 (fibronectin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40617/css/js/img/logo-atlas-4.svg