FOSB (FosB proto-oncogene, AP-1 transcription factor subunit)

2003-02-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
AP-1,G0S3,GOS3,GOSB
FUSION GENES

Other Information

Locus ID:

NCBI: 2354
MIM: 164772
HGNC: 3797
Ensembl: ENSG00000125740

Variants:

dbSNP: 2354
ClinVar: 2354
TCGA: ENSG00000125740
COSMIC: FOSB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125740ENST00000353609P53539
ENSG00000125740ENST00000353609A0A024R0P6
ENSG00000125740ENST00000417353P53539
ENSG00000125740ENST00000443841P53539
ENSG00000125740ENST00000585836P53539
ENSG00000125740ENST00000586615P53539
ENSG00000125740ENST00000589593K7EKA0
ENSG00000125740ENST00000590335K7EJ89
ENSG00000125740ENST00000591858P53539
ENSG00000125740ENST00000592436K7EKC1
ENSG00000125740ENST00000592811K7ERZ8
ENSG00000125740ENST00000615753P53539

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA283MAPK8GenePathwayassociated23922006
PA30621MAPK14GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
191336512009MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma.72
208267762010Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis.67
184906532008cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo.65
182071342008Genes controlling affiliative behavior as candidate genes for autism.56
254465622015∆FosB: a transcriptional regulator of stress and antidepressant responses.49
123719062003A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers.42
188021132008Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-gamma via superinduction of ATF-3 and suppression of AP-1.28
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
243749782014A novel SERPINE1-FOSB fusion gene results in transcriptional up-regulation of FOSB in pseudomyogenic haemangioendothelioma.24
189772412008Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.20

Citation

Dessen P

FOSB (FosB proto-oncogene, AP-1 transcription factor subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40621/fosb