GDF9 (growth differentiation factor 9)

2003-12-01  

Identity

HGNC
GDF9
LOCATION
5q31.1
LOCUSID
2661
ALIAS
POF14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2661
MIM: 601918
HGNC: 4224
Ensembl: ENSG00000164404

Variants:

dbSNP: 2661
ClinVar: 2661
TCGA: ENSG00000164404
COSMIC: GDF9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164404ENST00000296875B4DXG3
ENSG00000164404ENST00000378673O60383
ENSG00000164404ENST00000621295B4DXG3
ENSG00000164404ENST00000624492B4DXG3
ENSG00000164404ENST00000624495B4DXG3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386431612024GDF9(His209GlnfsTer6/S428T) and GDF9(Q321X/S428T) bi-allelic variants caused female subfertility with defective follicle enlargement.0
386431612024GDF9(His209GlnfsTer6/S428T) and GDF9(Q321X/S428T) bi-allelic variants caused female subfertility with defective follicle enlargement.0
363729882023Serum GDF9 and BMP15 as potential markers of ovarian function in women with and without polycystic ovary syndrome.5
366890452023Decreased GDF9 and BMP15 in follicle fluid and granulosa cells and outcomes of IVF-ET among young patients with low prognosis.2
380288402023Interleukin 17 and Growth Differentiation Factor 9 Influence in a Sample of Iraqi Infertile Males.0
363729882023Serum GDF9 and BMP15 as potential markers of ovarian function in women with and without polycystic ovary syndrome.5
366890452023Decreased GDF9 and BMP15 in follicle fluid and granulosa cells and outcomes of IVF-ET among young patients with low prognosis.2
380288402023Interleukin 17 and Growth Differentiation Factor 9 Influence in a Sample of Iraqi Infertile Males.0
348455752022GDF9 concentration in embryo culture medium is linked to human embryo quality and viability.2
348455752022GDF9 concentration in embryo culture medium is linked to human embryo quality and viability.2
333974082021Age-related decline in the expression of GDF9 and BMP15 genes in follicle fluid and granulosa cells derived from poor ovarian responders.10
337398002021Association of FSHR, LH, LHR, BMP15, GDF9, AMH, and AMHR polymorphisms with poor ovarian response in patients undergoing in vitro fertilization.4
337724132021New insights into the GDF9-Hedgehog-GLI signaling pathway in human ovaries: from fetus to postmenopause.2
337970062021A homozygous truncating variant in GDF9 in siblings with primary ovarian insufficiency.2
333974082021Age-related decline in the expression of GDF9 and BMP15 genes in follicle fluid and granulosa cells derived from poor ovarian responders.10

Citation

Dessen P

GDF9 (growth differentiation factor 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40704/js/favicon/apple-touch-icon.png