GGT1 (gamma-glutamyltransferase 1)

2003-06-01  

Identity

HGNC
GGT1
LOCATION
22q11.23
LOCUSID
2678
ALIAS
CD224,D22S672,D22S732,GGT,GGT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2678
MIM: 612346
HGNC: 4250
Ensembl: ENSG00000286070

Variants:

dbSNP: 2678
ClinVar: 2678
TCGA: ENSG00000286070
COSMIC: GGT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000286070ENST00000248923P19440
ENSG00000286070ENST00000248923A0A140VJJ9
ENSG00000286070ENST00000439775H3BT13

Pathways

PathwaySourceExternal ID
Taurine and hypotaurine metabolismKEGGko00430
Glutathione metabolismKEGGko00480
Arachidonic acid metabolismKEGGko00590
Taurine and hypotaurine metabolismKEGGhsa00430
Glutathione metabolismKEGGhsa00480
Arachidonic acid metabolismKEGGhsa00590
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)REACTOMER-HSA-2142691
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Glutathione synthesis and recyclingREACTOMER-HSA-174403
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646

References

Pubmed IDYearTitleCitations
184649132008A genome-wide association study identifies protein quantitative trait loci (pQTLs).184
189403122008Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.150
206484722010PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease.105
170957172007Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study.103
156949412005Association between serum gamma-glutamyltransferase and C-reactive protein.34
246133622014Baseline gamma-glutamyl transferase levels strongly correlate with hepatocellular carcinoma development in non-cirrhotic patients with successful hepatitis C virus eradication.34
184832832008Association of gamma-glutamyltransferase and risk of cancer incidence in men: a prospective study.33
223345652012Fatty liver index, gamma-glutamyltransferase, and early carotid plaques.33
205389602010A candidate gene study of obstructive sleep apnea in European Americans and African Americans.30
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27

Citation

Dessen P

GGT1 (gamma-glutamyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40709/ggt1