GH1 (growth hormone 1)

2003-02-01 Affiliation

Identity

HGNC

GH1

LOCATION

17q23.3

LOCUSID

2688

ALIAS

GH,GH-N,GHB5,GHN,IGHD1A,IGHD1B,IGHD2,hGH-N

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2688
MIM: 139250
HGNC: 4261
Ensembl: ENSG00000259384

Variants:

dbSNP: 2688
ClinVar: 2688
TCGA: ENSG00000259384
COSMIC: GH1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000259384	ENST00000323322	P01241
ENSG00000259384	ENST00000323322	B1A4G6
ENSG00000259384	ENST00000342364	B1A4G9
ENSG00000259384	ENST00000351388	P01241
ENSG00000259384	ENST00000458650	P01241
ENSG00000259384	ENST00000458650	B1A4G7
ENSG00000259384	ENST00000617086	B1A4H0

Expression (GTEx)

10000

20000

30000

40000

50000

60000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Neuroactive ligand-receptor interaction	KEGG	ko04080
Jak-STAT signaling pathway	KEGG	ko04630
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Jak-STAT signaling pathway	KEGG	hsa04630
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Synthesis, secretion, and deacylation of Ghrelin	REACTOME	R-HSA-422085
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Growth hormone receptor signaling	REACTOME	R-HSA-982772
Prolactin receptor signaling	REACTOME	R-HSA-1170546

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

thyroid gland

parathyroid gland

adrenal gland

pituitary gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

seminal vesicle

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

bone marrow

References

Pubmed ID	Year	Title	Citations
16543404	2006	Growth hormone regulation of sex-dependent liver gene expression.	138
17234973	2007	Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.	85
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19075184	2009	Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.	50
11864603	2002	A defined locus control region determinant links chromatin domain acetylation with long-range gene activation.	49
12428212	2002	Transcription factor SOX3 is involved in X-linked mental retardation with growth hormone deficiency.	43
19797429	2009	Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5.	39
20734064	2010	A large-scale candidate gene association study of age at menarche and age at natural menopause.	38
21849508	2011	Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes.	36
15353581	2004	Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone.	35

Citation

Dessen P

GH1 (growth hormone 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40711/gh1