ADGRG1 (adhesion G protein-coupled receptor G1)

2015-03-01  

Identity

HGNC
ADGRG1
LOCATION
16q21
LOCUSID
9289
ALIAS
BFPP,BPPR,GPR56,TM7LN4,TM7XN1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9289
MIM: 604110
HGNC: 4512
Ensembl: ENSG00000205336

Variants:

dbSNP: 9289
ClinVar: 9289
TCGA: ENSG00000205336
COSMIC: ADGRG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205336ENST00000388813Q9Y653
ENSG00000205336ENST00000388813A0A0S2Z517
ENSG00000205336ENST00000456916Q9Y653
ENSG00000205336ENST00000540164Q9Y653
ENSG00000205336ENST00000540164A0A0S2Z517
ENSG00000205336ENST00000561696H3BQ46
ENSG00000205336ENST00000561782H3BP67
ENSG00000205336ENST00000561833H3BVD3
ENSG00000205336ENST00000561969H3BQZ1
ENSG00000205336ENST00000561988H3BRH0
ENSG00000205336ENST00000562003H3BMY9
ENSG00000205336ENST00000562414H3BS14
ENSG00000205336ENST00000562467H3BRI2
ENSG00000205336ENST00000562558Q9Y653
ENSG00000205336ENST00000562558A0A0S2Z517
ENSG00000205336ENST00000562631Q9Y653
ENSG00000205336ENST00000562631A0A0S2Z517
ENSG00000205336ENST00000562682H3BSR1
ENSG00000205336ENST00000563007H3BUF5
ENSG00000205336ENST00000563374H3BP94
ENSG00000205336ENST00000563414H3BRA1
ENSG00000205336ENST00000563445H3BT88
ENSG00000205336ENST00000563548H3BM73
ENSG00000205336ENST00000563862H3BUU6
ENSG00000205336ENST00000564103H3BV84
ENSG00000205336ENST00000564338H3BUI6
ENSG00000205336ENST00000564360H3BTK9
ENSG00000205336ENST00000564722H3BS94
ENSG00000205336ENST00000564729H3BQW4
ENSG00000205336ENST00000564907H3BPC0
ENSG00000205336ENST00000565013H3BMF8
ENSG00000205336ENST00000565314H3BRZ4
ENSG00000205336ENST00000565338H3BTD2
ENSG00000205336ENST00000565391H3BSJ6
ENSG00000205336ENST00000565539H3BUF5
ENSG00000205336ENST00000565587H3BSN3
ENSG00000205336ENST00000565770H3BS98
ENSG00000205336ENST00000565976H3BNN3
ENSG00000205336ENST00000566123H3BVE9
ENSG00000205336ENST00000566164H3BSB8
ENSG00000205336ENST00000566169H3BRI7
ENSG00000205336ENST00000566187H3BTH7
ENSG00000205336ENST00000566271H3BNH4
ENSG00000205336ENST00000566508H3BPC0
ENSG00000205336ENST00000566778H3BSP5
ENSG00000205336ENST00000567154H3BSB8
ENSG00000205336ENST00000567397H3BPA6
ENSG00000205336ENST00000567553H3BQJ9
ENSG00000205336ENST00000567702H3BSN7
ENSG00000205336ENST00000567835Q9Y653
ENSG00000205336ENST00000567835A0A024R6U7
ENSG00000205336ENST00000567915H3BRI2
ENSG00000205336ENST00000568074H3BVE9
ENSG00000205336ENST00000568157H3BS94
ENSG00000205336ENST00000568234H3BVA0
ENSG00000205336ENST00000568531H3BSF7
ENSG00000205336ENST00000568618H3BNN3
ENSG00000205336ENST00000568645H3BUF5
ENSG00000205336ENST00000568791H3BMC2
ENSG00000205336ENST00000568908Q9Y653
ENSG00000205336ENST00000568908A0A0S2Z517
ENSG00000205336ENST00000568909Q9Y653
ENSG00000205336ENST00000568909A0A024R6U7
ENSG00000205336ENST00000568979H3BQ11
ENSG00000205336ENST00000569101H3BV52
ENSG00000205336ENST00000569154H3BS54
ENSG00000205336ENST00000569158H3BUH2
ENSG00000205336ENST00000569372H3BV72
ENSG00000205336ENST00000569494H3BQ46
ENSG00000205336ENST00000569531A0A1B0GX62
ENSG00000205336ENST00000570044H3BRB4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
150448052004G protein-coupled receptor-dependent development of human frontal cortex.140
167575642006GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis.87
245319682014Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning.70
259183802015Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist.52
217089462011The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity.50
255476742015Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation.41
217245882011GPR56 Regulates VEGF production and angiogenesis during melanoma progression.38
268342432016GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo.31
234786652013Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56.29
267108502016Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1).27

Citation

Dessen P

ADGRG1 (adhesion G protein-coupled receptor G1)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/40743/adgrg1