GRB7 (growth factor receptor bound protein 7)

2003-02-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 2886
MIM: 601522
HGNC: 4567
Ensembl: ENSG00000141738

Variants:

dbSNP: 2886
ClinVar: 2886
TCGA: ENSG00000141738
COSMIC: GRB7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141738ENST00000309156Q14451
ENSG00000141738ENST00000309156A0A0S2Z4F6
ENSG00000141738ENST00000394204Q14451
ENSG00000141738ENST00000394209Q14451
ENSG00000141738ENST00000394209A0A0S2Z4F6
ENSG00000141738ENST00000394211Q14451
ENSG00000141738ENST00000394211A0A0S2Z4F6
ENSG00000141738ENST00000445327Q14451
ENSG00000141738ENST00000577695J3QL76
ENSG00000141738ENST00000583813J3QKK7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Tie2 SignalingREACTOMER-HSA-210993
Signal TransductionREACTOMER-HSA-162582
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
Signaling by ERBB2REACTOMER-HSA-1227986
GRB7 events in ERBB2 signalingREACTOMER-HSA-1306955
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
RET signalingREACTOMER-HSA-8853659

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196489262009Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.32
165957852006Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis.29
194739622009Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis.27
174267022007Combination treatment with Grb7 peptide and Doxorubicin or Trastuzumab (Herceptin) results in cooperative cell growth inhibition in breast cancer cells.26
118097692002Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7.24
179169062008GRB-7 facilitates HER-2/Neu-mediated signal transduction and tumor formation.24
191245062009Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.22
197175352010Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer.22
120212782002Association of Grb7 with phosphoinositides and its role in the regulation of cell migration.20
203888502010Differential functions of growth factor receptor-bound protein 7 (GRB7) and its variant GRB7v in ovarian carcinogenesis.20

Citation

Dessen P

GRB7 (growth factor receptor bound protein 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40750/grb7