GSTM5 (glutathione S-transferase mu 5)

2003-06-01  

Identity

HGNC
LOCATION
1p13.3
LOCUSID
ALIAS
GSTM5-5,GTM5
FUSION GENES

Other Information

Locus ID:

NCBI: 2949
MIM: 138385
HGNC: 4637
Ensembl: ENSG00000134201

Variants:

dbSNP: 2949
ClinVar: 2949
TCGA: ENSG00000134201
COSMIC: GSTM5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134201ENST00000256593P46439
ENSG00000134201ENST00000256593Q5T8R2
ENSG00000134201ENST00000369812Q5T8R1
ENSG00000134201ENST00000647711A0A3B3IRM5
ENSG00000134201ENST00000648974A0A3B3IU61

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
357296182022Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis.7
357296182022Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis.7
338027022021Anti-Cancer Effects and Tumor Marker Role of Glutathione S-Transferase Mu 5 in Human Bladder Cancer.10
338027022021Anti-Cancer Effects and Tumor Marker Role of Glutathione S-Transferase Mu 5 in Human Bladder Cancer.10
258976512016GSTM1 and GSTM5 Genetic Polymorphisms and Expression in Age-Related Macular Degeneration.6
258976512016GSTM1 and GSTM5 Genetic Polymorphisms and Expression in Age-Related Macular Degeneration.6
224105702012DNA methylation is associated with altered gene expression in AMD.65
224105702012DNA methylation is associated with altered gene expression in AMD.65
198560982010Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1.18
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.25
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
204854442010Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.13
208197782010MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.26
198560982010Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1.18
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.25

Citation

Dessen P

GSTM5 (glutathione S-transferase mu 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40772/gene-fusions-explorer/css/card-gene.css