HAT1 (histone acetyltransferase 1)

2003-02-01  

Identity

HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
KAT1
FUSION GENES

Other Information

Locus ID:

NCBI: 8520
MIM: 603053
HGNC: 4821
Ensembl: ENSG00000128708

Variants:

dbSNP: 8520
ClinVar: 8520
TCGA: ENSG00000128708
COSMIC: HAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128708ENST00000264108O14929
ENSG00000128708ENST00000412731F8WEW1
ENSG00000128708ENST00000457761F8W9G7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
281439042017AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1.37
236533572013Histone acetyltransferase 1 promotes homologous recombination in DNA repair by facilitating histone turnover.35
170529792007Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.25
184580782008Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance.25
184580782008Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance.25
258650652015The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF.20
222287742012Human histone acetyltransferase 1 protein preferentially acetylates H4 histone molecules in H3.1-H4 over H3.3-H4.15
248352502014Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex.15
272472662016The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation.12
307093802019Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer.9

Citation

Dessen P

HAT1 (histone acetyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40788/hat1