HDAC4 (histone deacetylase 4)

2003-02-01  

Identity

HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
AHO3,BDMR,HA6116,HD4,HDAC-4,HDAC-A,HDACA
FUSION GENES

Other Information

Locus ID:

NCBI: 9759
MIM: 605314
HGNC: 14063
Ensembl: ENSG00000068024

Variants:

dbSNP: 9759
ClinVar: 9759
TCGA: ENSG00000068024
COSMIC: HDAC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000068024ENST00000345617P56524
ENSG00000068024ENST00000430200H7C397
ENSG00000068024ENST00000445704H7BZT3
ENSG00000068024ENST00000446876C9J0X4
ENSG00000068024ENST00000454542C9J481
ENSG00000068024ENST00000543185P56524
ENSG00000068024ENST00000544989F5H0B1

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Epstein-Barr virus infectionKEGGhsa05169
AlcoholismKEGGhsa05034
Epstein-Barr virus infectionKEGGko05169
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451609temozolomideChemicalMultilinkAnnotationassociated24444404

References

Pubmed IDYearTitleCitations
380573702024Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease.0
382175402024ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis.0
382811922024Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.0
380573702024Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease.0
382175402024ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis.0
382811922024Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.0
370104832023WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis.3
370138912023Circulating HDAC4 reflects lipid profile, coronary stenosis and inflammation in coronary heart disease patients.1
370524562023Silencing circular RNA hsa_circABCC1 inhibits osteosarcoma progression through down-regulating HDAC4 via sponging miR-591.1
370966532023LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low-density lipoprotein-induced injury of cardiac microvascular endothelial cells.1
377111682023Candidate Oligo Therapeutic Target, miR-330-3p, Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Cells via HDAC4.0
377690622023HDAC4 regulates the proliferation, migration, and invasion of trophoblasts in pre-eclampsia through the miR-134-5p/FOXM1 axis.0
380319872023Association between circHIPK3/miR-378a-3p/HDAC4 axis and osteoporotic fractures: A comprehensive investigation.1
370104832023WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis.3
370138912023Circulating HDAC4 reflects lipid profile, coronary stenosis and inflammation in coronary heart disease patients.1

Citation

Dessen P

HDAC4 (histone deacetylase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40805/cancer-prone-explorer/favicon/favicon-16x16.png