HDAC6 (histone deacetylase 6)

2003-11-01  

Identity

HGNC
LOCATION
Xp11.23
LOCUSID
ALIAS
CPBHM,HD6,JM21,PPP1R90
FUSION GENES

Other Information

Locus ID:

NCBI: 10013
MIM: 300272
HGNC: 14064
Ensembl: ENSG00000094631

Variants:

dbSNP: 10013
ClinVar: 10013
TCGA: ENSG00000094631
COSMIC: HDAC6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000094631ENST00000334136Q9UBN7
ENSG00000094631ENST00000334136A0A024QZ26
ENSG00000094631ENST00000376610A6NDI8
ENSG00000094631ENST00000376619Q9UBN7
ENSG00000094631ENST00000376619A0A024QZ26
ENSG00000094631ENST00000376643A6NDI8
ENSG00000094631ENST00000423941C9J172
ENSG00000094631ENST00000430858H7C0Z9
ENSG00000094631ENST00000438518C9JEF4
ENSG00000094631ENST00000440653E7ER52
ENSG00000094631ENST00000441703Q9BRX7
ENSG00000094631ENST00000443563E7EP63
ENSG00000094631ENST00000461608A0A2R8Y758
ENSG00000094631ENST00000462730Q9BRX7
ENSG00000094631ENST00000465269Q9BRX7
ENSG00000094631ENST00000476625A0A2R8Y5Z4
ENSG00000094631ENST00000480525A0A2R8Y6Z9
ENSG00000094631ENST00000486665A0A2R8YGC5
ENSG00000094631ENST00000489352A0A2R8Y5Z4
ENSG00000094631ENST00000642405A0A2R8Y559
ENSG00000094631ENST00000643374Q9UBN7
ENSG00000094631ENST00000643374A0A024QZ26
ENSG00000094631ENST00000643934A0A2R8YDE6
ENSG00000094631ENST00000644068Q9UBN7
ENSG00000094631ENST00000644068A0A024QZ26
ENSG00000094631ENST00000645643A0A2R8Y4G2
ENSG00000094631ENST00000646703A0A2R8YCS4
ENSG00000094631ENST00000647398A0A2R8YD35

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1 activationREACTOMER-HSA-3371511

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159169662005HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.367
159373402005Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.282
161922712005HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.270
176433702007HDAC6 modulates cell motility by altering the acetylation level of cortactin.230
178461732007Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.140
180791832007The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response.138
210765282011The role of HDAC6 in cancer.109
242006932013Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.107
186069872008HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation.103
199109242010Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6.102

Citation

Dessen P

HDAC6 (histone deacetylase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40807/hdac6