HDAC9 (histone deacetylase 9)

2003-05-01  

Identity

HGNC
LOCATION
7p21.1
LOCUSID
ALIAS
HD7,HD7b,HD9,HDAC,HDAC7,HDAC7B,HDAC9B,HDAC9FL,HDRP,MITR
FUSION GENES

Other Information

Locus ID:

NCBI: 9734
MIM: 606543
HGNC: 14065
Ensembl: ENSG00000048052

Variants:

dbSNP: 9734
ClinVar: 9734
TCGA: ENSG00000048052
COSMIC: HDAC9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000048052ENST00000401921Q9UKV0
ENSG00000048052ENST00000405010Q9UKV0
ENSG00000048052ENST00000406072B5MCF1
ENSG00000048052ENST00000406451Q9UKV0
ENSG00000048052ENST00000413380C9J1W4
ENSG00000048052ENST00000413509C9IZS0
ENSG00000048052ENST00000417496Q9UKV0
ENSG00000048052ENST00000428307Q9UKV0
ENSG00000048052ENST00000430454C9J835
ENSG00000048052ENST00000432645Q9UKV0
ENSG00000048052ENST00000433709C9JLX1
ENSG00000048052ENST00000441542Q9UKV0
ENSG00000048052ENST00000441986C9JD56
ENSG00000048052ENST00000446646F8WDS2
ENSG00000048052ENST00000456174Q9UKV0
ENSG00000048052ENST00000524023Q9UKV0
ENSG00000048052ENST00000622668B7Z3P7

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451846valproic acidChemicalPathwayassociated23407051

References

Pubmed IDYearTitleCitations
223066522012Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.166
173605652007FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression.146
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
151947492004Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
202982002010Confirmed rare copy number variants implicate novel genes in schizophrenia.54
155674132005Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2.38
212479012011Histone deacetylases 9 and 10 are required for homologous recombination.35
169803052006Alpha-actinin 4 potentiates myocyte enhancer factor-2 transcription activity by antagonizing histone deacetylase 7.31
179804132008Epigenetic regulation of established human type 1 versus type 2 cytokine responses.29

Citation

Dessen P

HDAC9 (histone deacetylase 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40808/hdac9-(histone-deacetylase-9)