HMGB1 (high mobility group box 1)

2003-02-01  

Identity

HGNC
LOCATION
13q12.3
LOCUSID
ALIAS
HMG-1,HMG1,HMG3,SBP-1
FUSION GENES

Other Information

Locus ID:

NCBI: 3146
MIM: 163905
HGNC: 4983
Ensembl: ENSG00000189403

Variants:

dbSNP: 3146
ClinVar: 3146
TCGA: ENSG00000189403
COSMIC: HMGB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189403ENST00000326004Q5T7C4
ENSG00000189403ENST00000339872P09429
ENSG00000189403ENST00000339872A0A024RDR0
ENSG00000189403ENST00000341423P09429
ENSG00000189403ENST00000341423A0A024RDR0
ENSG00000189403ENST00000399489Q5T7C4
ENSG00000189403ENST00000399494P09429
ENSG00000189403ENST00000399494A0A024RDR0
ENSG00000189403ENST00000405805P09429
ENSG00000189403ENST00000405805A0A024RDR0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Autophagy - animalKEGGko04140
Base excision repairKEGGhsa03410
Autophagy - animalKEGGhsa04140
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
TAK1 activates NFkB by phosphorylation and activation of IKKs complexREACTOMER-HSA-445989
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Advanced glycosylation endproduct receptor signalingREACTOMER-HSA-879415
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF6 mediated NF-kB activationREACTOMER-HSA-933542
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
ZBP1(DAI) mediated induction of type I IFNsREACTOMER-HSA-1606322
RIP-mediated NFkB activation via ZBP1REACTOMER-HSA-1810476
DEx/H-box helicases activate type I IFN and inflammatory cytokines productionREACTOMER-HSA-3134963
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227
Regulation of TLR by endogenous ligandREACTOMER-HSA-5686938
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121108902002Release of chromatin protein HMGB1 by necrotic cells triggers inflammation.1233
145321272003Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion.414
122315112002The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway.289
222937562012HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease.209
228423462012Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1.209
124565062003Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells.208
223707172012HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4.204
186314542008Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein.201
201230752010High-mobility group box 1 and cancer.187
221056042012Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1).186

Citation

Dessen P

HMGB1 (high mobility group box 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40834/hmgb1-(high-mobility-group-box-1)