HSPA1L (heat shock protein family A (Hsp70) member 1 like)

2003-08-01  

Identity

HGNC
HSPA1L
LOCATION
6p21.33
LOCUSID
3305
ALIAS
HSP70-1L,HSP70-HOM,HSP70T,hum70t
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3305
MIM: 140559
HGNC: 5234
Ensembl: ENSG00000204390

Variants:

dbSNP: 3305
ClinVar: 3305
TCGA: ENSG00000204390
COSMIC: HSPA1L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204390ENST00000375654P34931
ENSG00000204390ENST00000375654A0A1U9X7W7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Antigen processing and presentationKEGGko04612
MAPK signaling pathwayKEGGhsa04010
Antigen processing and presentationKEGGhsa04612
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Spliceosome, Prp19/CDC5L complexKEGGhsa_M00353
Spliceosome, 35S U5-snRNPKEGGhsa_M00355
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
Spliceosome, Prp19/CDC5L complexKEGGM00353
Spliceosome, 35S U5-snRNPKEGGM00355
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1-dependent transactivationREACTOMER-HSA-3371571
Attenuation phaseREACTOMER-HSA-3371568
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPD16538175
PA448785carbamazepineChemicalClinicalAnnotationassociatedPD16538175

References

Pubmed IDYearTitleCitations
363455982023Analysis of the heat shock protein 70 (HSP70) genetic variants in nonsegmental vitiligo patients.1
363455982023Analysis of the heat shock protein 70 (HSP70) genetic variants in nonsegmental vitiligo patients.1
347965242022Expressions of HSPA1L and HSPA9 are associated with poor sperm quality of low-motility spermatozoa in fertile men.3
347965242022Expressions of HSPA1L and HSPA9 are associated with poor sperm quality of low-motility spermatozoa in fertile men.3
337421292021A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease.4
344294512021Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth.8
337421292021A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease.4
344294512021Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth.8
318166682020Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population.4
320394492020HSPA1L rs1061581 polymorphism is associated with the risk of preeclampsia in Han Chinese women.0
329718932020HSPA1L Enhances Cancer Stem Cell-Like Properties by Activating IGF1Rβ and Regulating β-Catenin Transcription.7
318166682020Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population.4
320394492020HSPA1L rs1061581 polymorphism is associated with the risk of preeclampsia in Han Chinese women.0
329718932020HSPA1L Enhances Cancer Stem Cell-Like Properties by Activating IGF1Rβ and Regulating β-Catenin Transcription.7
312286772019HSPA1L and HSPA1B gene polymorphisms and haplotypes are associated with idiopathic male infertility in Iranian population.6

Citation

Dessen P

HSPA1L (heat shock protein family A (Hsp70) member 1 like)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40873/js/css/card-gene.css