TCEA1 (transcription elongation factor A1)

2004-05-01  

Identity

HGNC
LOCATION
8q11.23
LOCUSID
ALIAS
GTF2S,SII,TCEA,TF2S,TFIIS
FUSION GENES

Other Information

Locus ID:

NCBI: 6917
MIM: 601425
HGNC: 11612
Ensembl: ENSG00000187735

Variants:

dbSNP: 6917
ClinVar: 6917
TCGA: ENSG00000187735
COSMIC: TCEA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187735ENST00000396401P23193
ENSG00000187735ENST00000518310E5RFI1
ENSG00000187735ENST00000518784E5RJ93
ENSG00000187735ENST00000519704E5RK46
ENSG00000187735ENST00000520534E5RIS7
ENSG00000187735ENST00000521604P23193
ENSG00000187735ENST00000521604A0A384MTX4
ENSG00000187735ENST00000522635B7Z4S1
ENSG00000187735ENST00000638322A0A1W2PS15
ENSG00000187735ENST00000640041A0A1W2PRL9
ENSG00000187735ENST00000640382A0A1W2PPZ5
ENSG00000187735ENST00000640873A0A1W2PPV7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription ElongationREACTOMER-HSA-167169
Tat-mediated elongation of the HIV-1 transcriptREACTOMER-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 TatREACTOMER-HSA-167200
HIV elongation arrest and recoveryREACTOMER-HSA-167287
Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
Pausing and recovery of HIV elongationREACTOMER-HSA-167290
Tat-mediated HIV elongation arrest and recoveryREACTOMER-HSA-167243
Pausing and recovery of Tat-mediated HIV elongationREACTOMER-HSA-167238
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129146992003Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage.129
166308162006Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates.47
215963122011RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression.46
153516372004Transcription factors IIF and IIS and nucleoside triphosphate substrates as dynamic probes of the human RNA polymerase II mechanism.24
145062792003Combinatorial control of human RNA polymerase II (RNAP II) pausing and transcript cleavage by transcription factor IIF, hepatitis delta antigen, and stimulatory factor II.18
167365002006CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas.15
207291542010Transcription factor IIS impacts UV-inhibited transcription.10
315195222019Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.4
210707922011RNA interference against transcription elongation factor SII does not support its role in transcription-coupled nucleotide excision repair.3

Citation

Dessen P

TCEA1 (transcription elongation factor A1)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/409/tcea1