ICAM3 (intercellular adhesion molecule 3)

2003-11-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
CD50,CDW50,ICAM-R
FUSION GENES

Other Information

Locus ID:

NCBI: 3385
MIM: 146631
HGNC: 5346
Ensembl: ENSG00000076662

Variants:

dbSNP: 3385
ClinVar: 3385
TCGA: ENSG00000076662
COSMIC: ICAM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000076662ENST00000160262P32942
ENSG00000076662ENST00000160262A0A024R7C1
ENSG00000076662ENST00000585439K7EMH0
ENSG00000076662ENST00000589249K7ELH4
ENSG00000076662ENST00000589261K7ERN2
ENSG00000076662ENST00000589580K7ERJ4
ENSG00000076662ENST00000590569K7EQC7
ENSG00000076662ENST00000592439K7EP52
ENSG00000076662ENST00000592945K7ERF0

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CD209 (DC-SIGN) signalingREACTOMER-HSA-5621575
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198984812009Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.131
179138072007Adhesion molecule interactions facilitate human immunodeficiency virus type 1-induced virological synapse formation between T cells.96
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
120213232002Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission.77
117991262002Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1.63
203313782010Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.29
199568472010ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB.26
149702262004DC-SIGN binds to HIV-1 glycoprotein 120 in a distinct but overlapping fashion compared with ICAM-2 and ICAM-3.25
117847232002A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting.24
221171982012Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells.24

Citation

Dessen P

ICAM3 (intercellular adhesion molecule 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40911/icam3