IFNG (interferon gamma)

2003-08-01 Affiliation

Identity

HGNC

IFNG

LOCATION

12q15

LOCUSID

3458

ALIAS

IFG,IFI,IMD69

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3458
MIM: 147570
HGNC: 5438
Ensembl: ENSG00000111537

Variants:

dbSNP: 3458
ClinVar: 3458
TCGA: ENSG00000111537
COSMIC: IFNG

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000111537	ENST00000229135	P01579

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Proteasome	KEGG	ko03050
Cytokine-cytokine receptor interaction	KEGG	ko04060
TGF-beta signaling pathway	KEGG	ko04350
Antigen processing and presentation	KEGG	ko04612
Jak-STAT signaling pathway	KEGG	ko04630
Natural killer cell mediated cytotoxicity	KEGG	ko04650
T cell receptor signaling pathway	KEGG	ko04660
Type I diabetes mellitus	KEGG	ko04940
Systemic lupus erythematosus	KEGG	ko05322
Allograft rejection	KEGG	ko05330
Graft-versus-host disease	KEGG	ko05332
Proteasome	KEGG	hsa03050
Cytokine-cytokine receptor interaction	KEGG	hsa04060
TGF-beta signaling pathway	KEGG	hsa04350
Antigen processing and presentation	KEGG	hsa04612
Jak-STAT signaling pathway	KEGG	hsa04630
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
T cell receptor signaling pathway	KEGG	hsa04660
Type I diabetes mellitus	KEGG	hsa04940
Systemic lupus erythematosus	KEGG	hsa05322
Allograft rejection	KEGG	hsa05330
Graft-versus-host disease	KEGG	hsa05332
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Malaria	KEGG	ko05144
Malaria	KEGG	hsa05144
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
African trypanosomiasis	KEGG	ko05143
African trypanosomiasis	KEGG	hsa05143
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Salmonella infection	KEGG	ko05132
Salmonella infection	KEGG	hsa05132
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
HIF-1 signaling pathway	KEGG	hsa04066
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon gamma signaling	REACTOME	R-HSA-877300
Regulation of IFNG signaling	REACTOME	R-HSA-877312
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659
IL-17 signaling pathway	KEGG	ko04657
Fluid shear stress and atherosclerosis	KEGG	ko05418
IL-17 signaling pathway	KEGG	hsa04657
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164713366	Tumor necrosis factor alpha (TNF-alpha) inhibitors	Chemical	ClinicalAnnotation	associated	PD	24776844
PA443815	Crohn Disease	Disease	ClinicalAnnotation	associated	PD	24776844
PA446116	Inflammatory Bowel Diseases	Disease	ClinicalAnnotation	associated	PD	24776844

References

Pubmed ID	Year	Title	Citations
11984595	2002	Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis.	445
22466287	2012	Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.	294
18275276	2008	Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.	286
19458616	2009	Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus.	247
11900986	2002	The roles of IFN gamma in protection against tumor development and cancer immunoediting.	229
15778222	2005	Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death.	210
15681825	2005	Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.	204
18497880	2008	Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis.	200
17363736	2007	Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway.	197
21430066	2011	Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors.	183

Citation

Dessen P

IFNG (interferon gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40925/ifng-(interferon-gamma)