IL12A (interleukin 12A)

2003-08-01  

Identity

HGNC
IL12A
LOCATION
3q25.33
LOCUSID
3592
ALIAS
CLMF,IL-12A,NFSK,NKSF1,P35

Other Information

Locus ID:

NCBI: 3592
MIM: 161560
HGNC: 5969
Ensembl: ENSG00000168811

Variants:

dbSNP: 3592
ClinVar: 3592
TCGA: ENSG00000168811
COSMIC: IL12A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168811ENST00000305579P29459
ENSG00000168811ENST00000305579O60595
ENSG00000168811ENST00000466512E9PGR3
ENSG00000168811ENST00000480787E7ENE1

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Toll-like receptor signaling pathwayKEGGko04620
Jak-STAT signaling pathwayKEGGko04630
Type I diabetes mellitusKEGGko04940
Allograft rejectionKEGGko05330
Cytokine-cytokine receptor interactionKEGGhsa04060
Toll-like receptor signaling pathwayKEGGhsa04620
Jak-STAT signaling pathwayKEGGhsa04630
Type I diabetes mellitusKEGGhsa04940
Allograft rejectionKEGGhsa05330
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MalariaKEGGko05144
MalariaKEGGhsa05144
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Influenza AKEGGko05164
Influenza AKEGGhsa05164
PertussisKEGGko05133
PertussisKEGGhsa05133
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467
Interleukin-12 signalingREACTOMER-HSA-447115
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPD21107304
PA166048654ustekinumabChemicalLabelAnnotationassociated
PA450566mycophenolate mofetilChemicalClinicalAnnotationassociatedPD21107304

References

Pubmed IDYearTitleCitations
382780312024Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes.1
386902862024The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis.0
382780312024Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes.1
386902862024The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis.0
359597142023Immunomodulatory effect of IL-35 gene-transfected mesenchymal stem cells on allergic asthma.4
371958202023A Meta-Analysis of the Association Between Genetic Polymorphisms in IL-12, IL-17, and IL-21 and Risk of Hepatitis B Virus Infection.0
373269772023IL-8 and IL-12p70 are associated with pelvic pain among infertile women with endometriosis.1
378787032023Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions.2
382035752023Altered Gene Expression of IL-35 and IL-36α in the Skin of Patients with Atopic Dermatitis.1
359597142023Immunomodulatory effect of IL-35 gene-transfected mesenchymal stem cells on allergic asthma.4
371958202023A Meta-Analysis of the Association Between Genetic Polymorphisms in IL-12, IL-17, and IL-21 and Risk of Hepatitis B Virus Infection.0
373269772023IL-8 and IL-12p70 are associated with pelvic pain among infertile women with endometriosis.1
378787032023Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions.2
382035752023Altered Gene Expression of IL-35 and IL-36α in the Skin of Patients with Atopic Dermatitis.1
338781822022Altered CD4+ T cell and cytokine levels in peripheral blood and skin samples from systemic sclerosis patients and IL-35 in CD4+ T cell growth.8

Citation

Dessen P

IL12A (interleukin 12A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40940/haematological-explorer/css/js/lib/all.min.js