IL1A (interleukin 1 alpha)

2003-08-01  

Identity

HGNC
IL1A
LOCATION
2q14.1
LOCUSID
3552
ALIAS
IL-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3552
MIM: 147760
HGNC: 5991
Ensembl: ENSG00000115008

Variants:

dbSNP: 3552
ClinVar: 3552
TCGA: ENSG00000115008
COSMIC: IL1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115008ENST00000263339P01583

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Cytokine-cytokine receptor interactionKEGGko04060
Hematopoietic cell lineageKEGGko04640
Type I diabetes mellitusKEGGko04940
Graft-versus-host diseaseKEGGko05332
MAPK signaling pathwayKEGGhsa04010
Cytokine-cytokine receptor interactionKEGGhsa04060
Hematopoietic cell lineageKEGGhsa04640
Type I diabetes mellitusKEGGhsa04940
Graft-versus-host diseaseKEGGhsa05332
Prion diseasesKEGGko05020
Prion diseasesKEGGhsa05020
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Influenza AKEGGko05164
Influenza AKEGGhsa05164
PertussisKEGGko05133
PertussisKEGGhsa05133
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 processingREACTOMER-HSA-448706
Interleukin-1 signalingREACTOMER-HSA-446652
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD21107309
PA450688olanzapineChemicalClinicalAnnotationassociatedPD21107309

References

Pubmed IDYearTitleCitations
367927942024Serum Interleukin-1 Levels Are Associated with Intracranial Aneurysm Instability.2
379030652024Group B streptococcus induces cellular senescence in human amnion epithelial cells through a partial interleukin-1-mediated mechanism.0
382253482024Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells.0
385133092024Association of genetic polymorphism of interleukin 1-alpha and interleukin 1-beta with external apical root resorption in orthodontic patients.0
386786262024Correlations of IL-1 and IL-6 Gene polymorphisms with hypertrophic cardiomyopathy.0
387233692024Processing of angiocrine alarmin IL-1α in endothelial cells promotes lung and liver fibrosis.0
387772112024Interleukin-1 increases SERPINE1 expression in human granulosa-lutein cell via P50/P52 signaling pathways.0
367927942024Serum Interleukin-1 Levels Are Associated with Intracranial Aneurysm Instability.2
379030652024Group B streptococcus induces cellular senescence in human amnion epithelial cells through a partial interleukin-1-mediated mechanism.0
382253482024Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells.0
385133092024Association of genetic polymorphism of interleukin 1-alpha and interleukin 1-beta with external apical root resorption in orthodontic patients.0
386786262024Correlations of IL-1 and IL-6 Gene polymorphisms with hypertrophic cardiomyopathy.0
387233692024Processing of angiocrine alarmin IL-1α in endothelial cells promotes lung and liver fibrosis.0
387772112024Interleukin-1 increases SERPINE1 expression in human granulosa-lutein cell via P50/P52 signaling pathways.0
361680032023Increased IL-1α expression in chronic rhinosinusitis with nasal polyps.0

Citation

Dessen P

IL1A (interleukin 1 alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40949/cancer-prone-explorer/css/lib/js/lib/css/template-card.css