IL1A (interleukin 1 alpha)

2003-08-01  

Identity

HGNC
LOCATION
2q14.1
LOCUSID
ALIAS
IL-1
FUSION GENES

Other Information

Locus ID:

NCBI: 3552
MIM: 147760
HGNC: 5991
Ensembl: ENSG00000115008

Variants:

dbSNP: 3552
ClinVar: 3552
TCGA: ENSG00000115008
COSMIC: IL1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115008ENST00000263339P01583

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Cytokine-cytokine receptor interactionKEGGko04060
Hematopoietic cell lineageKEGGko04640
Type I diabetes mellitusKEGGko04940
Graft-versus-host diseaseKEGGko05332
MAPK signaling pathwayKEGGhsa04010
Cytokine-cytokine receptor interactionKEGGhsa04060
Hematopoietic cell lineageKEGGhsa04640
Type I diabetes mellitusKEGGhsa04940
Graft-versus-host diseaseKEGGhsa05332
Prion diseasesKEGGko05020
Prion diseasesKEGGhsa05020
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Influenza AKEGGko05164
Influenza AKEGGhsa05164
PertussisKEGGko05133
PertussisKEGGhsa05133
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 processingREACTOMER-HSA-448706
Interleukin-1 signalingREACTOMER-HSA-446652
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD21107309
PA450688olanzapineChemicalClinicalAnnotationassociatedPD21107309

References

Pubmed IDYearTitleCitations
191885312009Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.670
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
261472502015MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.210
122205472002The balance between IL-1 and IL-1Ra in disease.183
198050692009Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network.179
163891812006Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium.137
154892272004Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.131
119405702002Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression.121
205347412010Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.108
149830272004The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription.105

Citation

Dessen P

IL1A (interleukin 1 alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40949/il1a-(interleukin-1-alpha)