IL36G (interleukin 36 gamma)

2003-06-01  

Identity

HGNC
IL36G
LOCATION
2q14.1
LOCUSID
56300
ALIAS
IL-1F9,IL-1H1,IL-1RP2,IL1E,IL1F9,IL1H1,IL1RP2

Other Information

Locus ID:

NCBI: 56300
MIM: 605542
HGNC: 15741
Ensembl: ENSG00000136688

Variants:

dbSNP: 56300
ClinVar: 56300
TCGA: ENSG00000136688
COSMIC: IL36G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136688ENST00000259205Q9NZH8
ENSG00000136688ENST00000376489Q9NZH8
ENSG00000136688ENST00000447128C9J681

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

References

Pubmed IDYearTitleCitations
147345512004Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.121
212425152011IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression.83
219656792011Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity.82
248294172014IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.70
255257752015IL-36γ (IL-1F9) is a biomarker for psoriasis skin lesions.47
208708942011Regulation and function of the IL-1 family cytokine IL-1F9 in human bronchial epithelial cells.45
157017292005Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense.36
253053152014Alarmin function of cathelicidin antimicrobial peptide LL37 through IL-36γ induction in human epidermal keratinocytes.34
223183822012The double-stranded RNA analogue polyinosinic-polycytidylic acid induces keratinocyte pyroptosis and release of IL-36γ.33
230957522012IL-36γ/IL-1F9, an innate T-bet target in myeloid cells.28

Citation

Dessen P

IL36G (interleukin 36 gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40951/il36g