IL21 (interleukin 21)

2003-05-01  

Identity

HGNC
IL21
LOCATION
4q27
LOCUSID
59067
ALIAS
CVID11,IL-21,Za11

Other Information

Locus ID:

NCBI: 59067
MIM: 605384
HGNC: 6005
Ensembl: ENSG00000138684

Variants:

dbSNP: 59067
ClinVar: 59067
TCGA: ENSG00000138684
COSMIC: IL21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138684ENST00000611104Q9HBE4
ENSG00000138684ENST00000648588Q9HBE4
ENSG00000138684ENST00000648588A0A224B028

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

References

Pubmed IDYearTitleCitations
379724782024The role of Interleukin-21 in autoimmune Diseases: Mechanisms, therapeutic Implications, and future directions.1
386384312024Therapeutic potential of interleukin-21 in cancer.0
379724782024The role of Interleukin-21 in autoimmune Diseases: Mechanisms, therapeutic Implications, and future directions.1
386384312024Therapeutic potential of interleukin-21 in cancer.0
367385392023Characterization of peripheral blood T follicular helper (TFH) cells in patients with type 1 Gaucher disease and carriers.0
368724512023IL-21 boosts germinal center response through independent actions on T and B cells in a concentration-dependent manner.1
371076362023IL-21 (rs2055979 and rs2221903)/IL-21R (rs3093301) Polymorphism and High Levels of IL-21 Are Associated with Rheumatoid Arthritis in Mexican Patients.2
371958202023A Meta-Analysis of the Association Between Genetic Polymorphisms in IL-12, IL-17, and IL-21 and Risk of Hepatitis B Virus Infection.0
371960652023Clonally expanded, thyrotoxic effector CD8(+) T cells driven by IL-21 contribute to checkpoint inhibitor thyroiditis.6
372208052023Interleukin-21 promotes Type-1 activation and cytotoxicity of CD56(dim)CD16(bright) natural killer cells during kidney allograft antibody-mediated rejection showing a new link between adaptive and innate humoral allo-immunity.3
372496612023Implications of IL-21 in solid tumor therapy.3
373390512023A structural blueprint for interleukin-21 signal modulation.0
374159822023Evaluation of plasma IL-21 as a potential biomarker for type 1 diabetes progression.0
376287162023T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21.1
377595052023Interleukin-21 Influences Glioblastoma Course: Biological Mechanisms and Therapeutic Potential.1

Citation

Dessen P

IL21 (interleukin 21)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40954/css/template-nav.css