INSM1 (INSM transcriptional repressor 1)

2003-02-01  

Identity

HGNC
LOCATION
20p11.23
LOCUSID
ALIAS
IA-1,IA1

Other Information

Locus ID:

NCBI: 3642
MIM: 600010
HGNC: 6090
Ensembl: ENSG00000173404

Variants:

dbSNP: 3642
ClinVar: 3642
TCGA: ENSG00000173404
COSMIC: INSM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173404ENST00000310227Q01101

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Regulation of beta-cell developmentREACTOMER-HSA-186712
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cellsREACTOMER-HSA-210746

References

Pubmed IDYearTitleCitations
128906722003NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system.36
192464902009Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation.33
182052072008Transient expression of the conserved zinc finger gene INSM1 in progenitors and nascent neurons throughout embryonic and adult neurogenesis.30
165692152006INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases.24
264826082015Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer.20
118546182002Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells.16
202155682010Insulinoma-associated antigen-1 zinc-finger transcription factor promotes pancreatic duct cell trans-differentiation.15
184175292008Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription.14
287194692017INSM1 Demonstrates Superior Performance to the Individual and Combined Use of Synaptophysin, Chromogranin and CD56 for Diagnosing Neuroendocrine Tumors of the Thoracic Cavity.13
263860792015INSM1: A Novel Immunohistochemical and Molecular Marker for Neuroendocrine and Neuroepithelial Neoplasms.12

Citation

Dessen P

INSM1 (INSM transcriptional repressor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40985/insm1