IQGAP2 (IQ motif containing GTPase activating protein 2)

2003-11-01  

Identity

HGNC
IQGAP2
LOCATION
5q13.3
LOCUSID
10788
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10788
MIM: 605401
HGNC: 6111
Ensembl: ENSG00000145703

Variants:

dbSNP: 10788
ClinVar: 10788
TCGA: ENSG00000145703
COSMIC: IQGAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145703ENST00000274364Q13576
ENSG00000145703ENST00000379730F5H7S7
ENSG00000145703ENST00000396234Q13576
ENSG00000145703ENST00000502745Q13576
ENSG00000145703ENST00000504254D6R999
ENSG00000145703ENST00000504477H0YA28
ENSG00000145703ENST00000505766E7EWC2
ENSG00000145703ENST00000509074D6RDK8
ENSG00000145703ENST00000513534D6RGC6
ENSG00000145703ENST00000514001E9PDT6
ENSG00000145703ENST00000514350D6R939

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate IQGAPsREACTOMER-HSA-5626467
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
257222902015The biology of IQGAP proteins: beyond the cytoskeleton.45
200685912010A genome-wide association study for age-related hearing impairment in the Saami.34
200685912010A genome-wide association study for age-related hearing impairment in the Saami.34
125157162003IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization.22
209777432010IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma.22
179577822008IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.18
224062972012IQGAP2, A candidate tumour suppressor of prostate tumorigenesis.18
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12

Citation

Dessen P

IQGAP2 (IQ motif containing GTPase activating protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40988/iqgap2