ITGA7 (integrin subunit alpha 7)

2003-08-01  

Identity

HGNC
LOCATION
12q13.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 3679
MIM: 600536
HGNC: 6143
Ensembl: ENSG00000135424

Variants:

dbSNP: 3679
ClinVar: 3679
TCGA: ENSG00000135424
COSMIC: ITGA7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135424ENST00000257879Q13683
ENSG00000135424ENST00000347027J3KNV4
ENSG00000135424ENST00000452168Q13683
ENSG00000135424ENST00000553804Q13683
ENSG00000135424ENST00000553893G3V2Q6
ENSG00000135424ENST00000554327H0YJ26
ENSG00000135424ENST00000554724H0YJS5
ENSG00000135424ENST00000555687G3V3L8
ENSG00000135424ENST00000555728Q13683
ENSG00000135424ENST00000555809G3V2Q6
ENSG00000135424ENST00000556273G3V2I4
ENSG00000135424ENST00000557257G3V2C6
ENSG00000135424ENST00000557555H0YJ98

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Regulation of actin cytoskeletonKEGGhsa04810
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Extracellular matrix organizationREACTOMER-HSA-1474244
Laminin interactionsREACTOMER-HSA-3000157
ECM proteoglycansREACTOMER-HSA-3000178
Integrin cell surface interactionsREACTOMER-HSA-216083

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194168972009Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy.58
299438282018Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7.44
175511472007Analysis of integrin alpha7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma.39
151179622004The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor.32
286026202017Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma.31
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23
240913242013Integrins protect cardiomyocytes from ischemia/reperfusion injury.22
279248202016Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma.22
242277112013α6β1 and α7β1 integrins are required in Schwann cells to sort axons.19
170549472006alpha7 integrin expressing human fetal myogenic progenitors have stem cell-like properties and are capable of osteogenic differentiation.17

Citation

Dessen P

ITGA7 (integrin subunit alpha 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41008/itga7