ITGB7 (integrin subunit beta 7)

2003-08-01  

Identity

HGNC
ITGB7
LOCATION
12q13.13
LOCUSID
3695
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3695
MIM: 147559
HGNC: 6162
Ensembl: ENSG00000139626

Variants:

dbSNP: 3695
ClinVar: 3695
TCGA: ENSG00000139626
COSMIC: ITGB7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139626ENST00000267082P26010
ENSG00000139626ENST00000422257P26010
ENSG00000139626ENST00000542497F5H6T4
ENSG00000139626ENST00000549086F8W186
ENSG00000139626ENST00000550743P26010
ENSG00000139626ENST00000551319H3BRX4
ENSG00000139626ENST00000552935H3BRM2
ENSG00000139626ENST00000552972F8VNX4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Cell adhesion molecules (CAMs)KEGGko04514
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Cell adhesion molecules (CAMs)KEGGhsa04514
Regulation of actin cytoskeletonKEGGhsa04810
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083

References

Pubmed IDYearTitleCitations
387816592024Cryo-EM structure of I domain-containing integrin αEβ7.0
387816592024Cryo-EM structure of I domain-containing integrin αEβ7.0
367378072023Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics.3
367378072023Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics.3
339993382021Expression of activated integrin β7 in multiple myeloma patients.7
341345782021Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis.11
339993382021Expression of activated integrin β7 in multiple myeloma patients.7
341345782021Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis.11
318164092020Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome.13
328412662020Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs.2
331667902020The association of α4β7 expression with HIV acquisition and disease progression in people who inject drugs and men who have sex with men: Case control studies.1
332887042020The V2 loop of HIV gp120 delivers costimulatory signals to CD4(+) T cells through Integrin α(4)β(7) and promotes cellular activation and infection.12
318164092020Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome.13
328412662020Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs.2
331667902020The association of α4β7 expression with HIV acquisition and disease progression in people who inject drugs and men who have sex with men: Case control studies.1

Citation

Dessen P

ITGB7 (integrin subunit beta 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41023/gene-fusions/gene-fusions-explorer/css/template-nav.css