ITGB7 (integrin subunit beta 7)

2003-08-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 3695
MIM: 147559
HGNC: 6162
Ensembl: ENSG00000139626

Variants:

dbSNP: 3695
ClinVar: 3695
TCGA: ENSG00000139626
COSMIC: ITGB7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139626ENST00000267082P26010
ENSG00000139626ENST00000422257P26010
ENSG00000139626ENST00000542497F5H6T4
ENSG00000139626ENST00000549086F8W186
ENSG00000139626ENST00000550743P26010
ENSG00000139626ENST00000551319H3BRX4
ENSG00000139626ENST00000552935H3BRM2
ENSG00000139626ENST00000552972F8VNX4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Cell adhesion molecules (CAMs)KEGGko04514
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Cell adhesion molecules (CAMs)KEGGhsa04514
Regulation of actin cytoskeletonKEGGhsa04810
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083

References

Pubmed IDYearTitleCitations
199333302009The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.133
219269992011Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.121
173251972007Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis.77
146083742003Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster.68
213986062011Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7.64
188294552008Structural basis of the migfilin-filamin interaction and competition with integrin beta tails.50
241627742013The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.44
214746702011Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion.37
156991712005L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine.36
196992112009The regulation mechanism for the auto-inhibition of binding of human filamin A to integrin.32

Citation

Dessen P

ITGB7 (integrin subunit beta 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41023/itgb7-(integrin-subunit-beta-7)