FBXO42 (F-box protein 42)

2003-05-01  

Identity

HGNC
FBXO42
LOCATION
1p36.13
LOCUSID
54455
ALIAS
Fbx42,JFK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54455
MIM: 609109
HGNC: 29249
Ensembl: ENSG00000037637

Variants:

dbSNP: 54455
ClinVar: 54455
TCGA: ENSG00000037637
COSMIC: FBXO42

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000037637ENST00000375592Q6P3S6
ENSG00000037637ENST00000375592A0A024QZB0
ENSG00000037637ENST00000444116X6RKU3
ENSG00000037637ENST00000456164X6RKU3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
315497672020A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma.11
315497672020A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma.11
257926012015SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer.27
257926012015SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer.27
240636882013Genetic analysis of the FBXO42 gene in Chinese Han patients with Parkinson's disease.1
240636882013Genetic analysis of the FBXO42 gene in Chinese Han patients with Parkinson's disease.1
211270742011Substrate phosphorylation and feedback regulation in JFK-promoted p53 destabilization.14
211270742011Substrate phosphorylation and feedback regulation in JFK-promoted p53 destabilization.14
195093322009JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation.48
195093322009JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation.48

Citation

Dessen P

FBXO42 (F-box protein 42)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41064/favicon/js/_common.js