KLF12 (Kruppel like factor 12)

KLF12 (Kruppel like factor 12)

2003-06-01 Affiliation

Identity

HGNC

LOCATION

13q22.1

LOCUSID

ALIAS

AP-2rep,AP2REP,HSPC122

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 11278
MIM: 607531
HGNC: 6346
Ensembl: ENSG00000118922

Variants:

dbSNP: 11278
ClinVar: 11278
TCGA: ENSG00000118922
COSMIC: KLF12

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000118922	ENST00000377669	Q9Y4X4

Expression (GTEx)

0

5

10

15

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37156774	2023	KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner.	3
37290172	2023	MiR-17-5p promoter methylation regulated by DNA methyltransferase 3 beta (DNMT3B) expedites endometriosis via the Krüppel-like factor 12 (KLF12)/Wnt/β-catenin axis.	1
37543362	2023	Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production.	0
37606530	2023	KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.	0
37698263	2023	Circ_0084188 promotes colorectal cancer progression by sponging miR-654-3p and regulating kruppel-like factor 12.	1
37156774	2023	KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner.	3
37290172	2023	MiR-17-5p promoter methylation regulated by DNA methyltransferase 3 beta (DNMT3B) expedites endometriosis via the Krüppel-like factor 12 (KLF12)/Wnt/β-catenin axis.	1
37543362	2023	Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production.	0
37606530	2023	KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.	0
37698263	2023	Circ_0084188 promotes colorectal cancer progression by sponging miR-654-3p and regulating kruppel-like factor 12.	1
36272152	2022	MicroRNA-650 suppresses KLF12 expression to regulate growth and metastasis of human ovarian cancer cells.	2
36272152	2022	MicroRNA-650 suppresses KLF12 expression to regulate growth and metastasis of human ovarian cancer cells.	2
33279628	2021	Krüppel-like factor 12 suppresses bladder cancer growth through transcriptionally inhibition of enolase 2.	10
34117589	2021	Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis.	5
34461926	2021	Circ-RNF111 aggravates the malignancy of gastric cancer through miR-876-3p-dependent regulation of KLF12.	9

Citation

Dessen P

KLF12 (Kruppel like factor 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41073/js/cancer-prone-explorer/js/web-card-gene.js