KPNA1 (karyopherin subunit alpha 1)

2003-05-01  

Identity

HGNC
LOCATION
3q21.1
LOCUSID
ALIAS
IPOA5,NPI-1,RCH2,SRP1
FUSION GENES

Other Information

Locus ID:

NCBI: 3836
MIM: 600686
HGNC: 6394
Ensembl: ENSG00000114030

Variants:

dbSNP: 3836
ClinVar: 3836
TCGA: ENSG00000114030
COSMIC: KPNA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114030ENST00000344337P52294
ENSG00000114030ENST00000465882C9JYI4
ENSG00000114030ENST00000476916C9J352
ENSG00000114030ENST00000482287C9J4U1
ENSG00000114030ENST00000485027F2Z3G4
ENSG00000114030ENST00000493510C9JWD9
ENSG00000114030ENST00000494339F2Z3G4

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Influenza AKEGGko05164
Influenza AKEGGhsa05164
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Early Phase of HIV Life CycleREACTOMER-HSA-162594
Integration of provirusREACTOMER-HSA-162592
Host Interactions of HIV factorsREACTOMER-HSA-162909
Interactions of Vpr with host cellular proteinsREACTOMER-HSA-176033
Vpr-mediated nuclear import of PICsREACTOMER-HSA-180910
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Transport of Ribonucleoproteins into the Host NucleusREACTOMER-HSA-168271
Host Interactions with Influenza FactorsREACTOMER-HSA-168253
NS1 Mediated Effects on Host PathwaysREACTOMER-HSA-168276
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
179283502007Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.118
127403722003Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein.72
120481902002Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5.70
198897622010Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signaling.60
182387772008Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2.58
190666262008The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication.49
162985122006Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements.45
264144022015Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module.45
164395542006Nuclear import of Epstein-Barr virus nuclear antigen 1 mediated by NPI-1 (Importin alpha5) is up- and down-regulated by phosphorylation of the nuclear localization signal for which Lys379 and Arg380 are essential.28
204068042010Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening.24

Citation

Dessen P

KPNA1 (karyopherin subunit alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41096/kpna1-(karyopherin-subunit-alpha-1)