LRP1 (LDL receptor related protein 1)

2003-11-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
A2MR,APOER,APR,CD91,IGFBP-3R,IGFBP3R,IGFBP3R1,KPA,LRP,LRP1A,TGFBR5
FUSION GENES

Other Information

Locus ID:

NCBI: 4035
MIM: 107770
HGNC: 6692
Ensembl: ENSG00000123384

Variants:

dbSNP: 4035
ClinVar: 4035
TCGA: ENSG00000123384
COSMIC: LRP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123384ENST00000243077Q07954
ENSG00000123384ENST00000338962Q07954
ENSG00000123384ENST00000553277Q7Z7K9
ENSG00000123384ENST00000554118H0YJI8
ENSG00000123384ENST00000554174Q6PJ72
ENSG00000123384ENST00000555124H0YJ88

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Alzheimer's diseaseKEGGko05010
Alzheimer's diseaseKEGGhsa05010
MalariaKEGGko05144
MalariaKEGGhsa05144
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging of heme from plasmaREACTOMER-HSA-2168880
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA150595617platinumChemicalLiteraturenot associated24643204

References

Pubmed IDYearTitleCitations
152941422004LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.296
129609612003Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator.146
176940662007Clearance of amyloid-beta by circulating lipoprotein receptors.142
273225432016Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.108
157497092005The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.95
184897122008Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2.87
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
117291932002Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).79
119070442002Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain.79
150015792004The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1.73

Citation

Dessen P

LRP1 (LDL receptor related protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41199/lrp1