LRRFIP2 (LRR binding FLII interacting protein 2)

2003-12-01  

Identity

HGNC
LOCATION
3p22.2
LOCUSID
ALIAS
HUFI-2
FUSION GENES

Other Information

Locus ID:

NCBI: 9209
MIM: 614043
HGNC: 6703
Ensembl: ENSG00000093167

Variants:

dbSNP: 9209
ClinVar: 9209
TCGA: ENSG00000093167
COSMIC: LRRFIP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000093167ENST00000336686Q9Y608
ENSG00000093167ENST00000354379Q9Y608
ENSG00000093167ENST00000396428Q9Y608
ENSG00000093167ENST00000416425C9JSU1
ENSG00000093167ENST00000421276Q9Y608
ENSG00000093167ENST00000434749C9JC17
ENSG00000093167ENST00000436858C9JJC9
ENSG00000093167ENST00000438374C9J0U5
ENSG00000093167ENST00000440230Q9Y608
ENSG00000093167ENST00000440742H7C3N9
ENSG00000093167ENST00000452742C9J321

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
156773332005Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.28
192651232009Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins.26
212204262011Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling.12
274314772016F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2.9
230361962012Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS.7
217853612011A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families.6

Citation

Dessen P

LRRFIP2 (LRR binding FLII interacting protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41205/lrrfip2