LTBP1 (latent transforming growth factor beta binding protein 1)

2003-12-01  

Identity

HGNC
LOCATION
2p22.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 4052
MIM: 150390
HGNC: 6714
Ensembl: ENSG00000049323

Variants:

dbSNP: 4052
ClinVar: 4052
TCGA: ENSG00000049323
COSMIC: LTBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000049323ENST00000402934C9JD84
ENSG00000049323ENST00000404525Q14766
ENSG00000049323ENST00000404816Q14766
ENSG00000049323ENST00000407925Q14766
ENSG00000049323ENST00000413303C9JDW2
ENSG00000049323ENST00000415140H7BZ76
ENSG00000049323ENST00000418533E7EV71
ENSG00000049323ENST00000422669H7C0I7
ENSG00000049323ENST00000432635H7C2H7
ENSG00000049323ENST00000468091H7C4L5

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Extracellular matrix organizationREACTOMER-HSA-1474244
Elastic fibre formationREACTOMER-HSA-1566948
Molecules associated with elastic fibresREACTOMER-HSA-2129379

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382661792024Targeted Mass Spectrometry of Longitudinal Patient Sera Reveals LTBP1 as a Potential Surveillance Biomarker for High-Grade Serous Ovarian Carcinoma.1
383584122024A prognostic marker LTBP1 is associated with epithelial mesenchymal transition and can promote the progression of gastric cancer.0
382661792024Targeted Mass Spectrometry of Longitudinal Patient Sera Reveals LTBP1 as a Potential Surveillance Biomarker for High-Grade Serous Ovarian Carcinoma.1
383584122024A prognostic marker LTBP1 is associated with epithelial mesenchymal transition and can promote the progression of gastric cancer.0
366295222023Immune suppressive signaling regulated by latent transforming growth factor beta binding protein 1 promotes metastasis in cervical cancer.1
366295222023Immune suppressive signaling regulated by latent transforming growth factor beta binding protein 1 promotes metastasis in cervical cancer.1
354528172022LTBP1 promotes fibrillin incorporation into the extracellular matrix.5
354528172022LTBP1 promotes fibrillin incorporation into the extracellular matrix.5
339914722021Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome.11
344115632021POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.4
339914722021Bi-allelic premature truncating variants in LTBP1 cause cutis laxa syndrome.11
344115632021POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.4
316280422020PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia.22
322168152020LTBP1 promotes esophageal squamous cell carcinoma progression through epithelial-mesenchymal transition and cancer-associated fibroblasts transformation.13
330597532020LTBP1 plays a potential bridge between depressive disorder and glioblastoma.8

Citation

Dessen P

LTBP1 (latent transforming growth factor beta binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41212/favicon/css/js/lib/zoomerang.js