LTBR (lymphotoxin beta receptor)

2003-06-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
D12S370,LT-BETA-R,TNF-R-III,TNFCR,TNFR-RP,TNFR2-RP,TNFR3,TNFRSF3
FUSION GENES

Other Information

Locus ID:

NCBI: 4055
MIM: 600979
HGNC: 6718
Ensembl: ENSG00000111321

Variants:

dbSNP: 4055
ClinVar: 4055
TCGA: ENSG00000111321
COSMIC: LTBR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111321ENST00000228918P36941
ENSG00000111321ENST00000536876F5H6F8
ENSG00000111321ENST00000541102F5H2E7
ENSG00000111321ENST00000543190F5H1S5
ENSG00000111321ENST00000544454F5H627

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
HIF-1 signaling pathwayKEGGhsa04066
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198005752009A lymphotoxin-driven pathway to hepatocellular carcinoma.138
124198172003The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536.61
169344972006Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure.53
173604022007Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid.42
182925732008Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells.31
201858192010TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor.31
203480962010Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor.30
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
235244632013Lymphotoxin signalling in immune homeostasis and the control of microorganisms.27
160027342005Contribution of the lymphotoxin beta receptor to liver regeneration.26

Citation

Dessen P

LTBR (lymphotoxin beta receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41216/ltbr