SMAD7 (SMAD family member 7)

2003-02-01  

Identity

HGNC
LOCATION
18q21.1
LOCUSID
ALIAS
CRCS3,MADH7,MADH8
FUSION GENES

Other Information

Locus ID:

NCBI: 4092
MIM: 602932
HGNC: 6773
Ensembl: ENSG00000101665

Variants:

dbSNP: 4092
ClinVar: 4092
TCGA: ENSG00000101665
COSMIC: SMAD7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101665ENST00000262158O15105
ENSG00000101665ENST00000586093K7EKF0
ENSG00000101665ENST00000589634O15105
ENSG00000101665ENST00000591805O15105

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by BMPREACTOMER-HSA-201451
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Downregulation of TGF-beta receptor signalingREACTOMER-HSA-2173788
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionREACTOMER-HSA-2173796
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
179344612007A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.235
222867702012The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer.126
193525402009Regulation of TGF-beta signaling by Smad7.116
174381442007Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation.94
147185192004GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor.88
125890522003Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3.85
243945552014microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition.85
173323632007Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis.80
186847122009Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva.77
226412182013TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers.77

Citation

Dessen P

SMAD7 (SMAD family member 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41232/smad7