MAP2K7 (mitogen-activated protein kinase kinase 7)

2003-08-01 Affiliation

Identity

HGNC

MAP2K7

LOCATION

19p13.2

LOCUSID

5609

ALIAS

JNKK2,MAPKK7,MEK,MEK

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5609
MIM: 603014
HGNC: 6847
Ensembl: ENSG00000076984

Variants:

dbSNP: 5609
ClinVar: 5609
TCGA: ENSG00000076984
COSMIC: MAP2K7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000076984	ENST00000397979	O14733
ENSG00000076984	ENST00000397981	O14733
ENSG00000076984	ENST00000397983	O14733

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
ErbB signaling pathway	KEGG	ko04012
Tight junction	KEGG	ko04530
Toll-like receptor signaling pathway	KEGG	ko04620
T cell receptor signaling pathway	KEGG	ko04660
Fc epsilon RI signaling pathway	KEGG	ko04664
GnRH signaling pathway	KEGG	ko04912
MAPK signaling pathway	KEGG	hsa04010
ErbB signaling pathway	KEGG	hsa04012
Tight junction	KEGG	hsa04530
Toll-like receptor signaling pathway	KEGG	hsa04620
T cell receptor signaling pathway	KEGG	hsa04660
Fc epsilon RI signaling pathway	KEGG	hsa04664
GnRH signaling pathway	KEGG	hsa04912
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
TNF signaling pathway	KEGG	hsa04668
TNF signaling pathway	KEGG	ko04668
MAPK (JNK) signaling	KEGG	hsa_M00688
MAPK (JNK) signaling	KEGG	M00688
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Uptake and actions of bacterial toxins	REACTOME	R-HSA-5339562
Uptake and function of anthrax toxins	REACTOME	R-HSA-5210891
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
MAP kinase activation in TLR cascade	REACTOME	R-HSA-450294
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	REACTOME	R-HSA-450321
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA283	MAPK8	Gene	Pathway	associated	20124951, 23922006
PA30592	MAP3K1	Gene	Pathway	associated	23922006
PA30616	MAPK1	Gene	Pathway	associated	20124951
PA30617	MAPK10	Gene	Pathway	associated	20124951
PA30618	MAPK11	Gene	Pathway	associated	20124951
PA30619	MAPK12	Gene	Pathway	associated	20124951
PA30620	MAPK13	Gene	Pathway	associated	20124951
PA30621	MAPK14	Gene	Pathway	associated	20124951
PA30622	MAPK3	Gene	Pathway	associated	20124951
PA30623	MAPK4	Gene	Pathway	associated	20124951
PA30624	MAPK6	Gene	Pathway	associated	20124951
PA30625	MAPK7	Gene	Pathway	associated	20124951
PA30630	MAPK9	Gene	Pathway	associated	20124951
PA34183	RAF1	Gene	Pathway	associated	20124951

References

Pubmed ID	Year	Title	Citations
16533805	2006	Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases.	34
17485467	2007	Insights into the structural basis of the GADD45beta-mediated inactivation of the JNK kinase, MKK7/JNKK2.	31
26443849	2015	Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation.	29
18222647	2008	Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism.	25
21074392	2012	Involvement of oxidative stress in taxol-induced apoptosis in chronic myelogenous leukemia K562 cells.	25
22903704	2013	Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity.	25
16802349	2006	Regulation of JNK by MKK-7 in fibroblast-like synoviocytes.	23
26351322	2015	Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors.	23
13130464	2003	Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK.	21
25737554	2015	Structure and dynamics of the MKK7-JNK signaling complex.	21

Citation

Dessen P

MAP2K7 (mitogen-activated protein kinase kinase 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41275/map2k7