MBD1 (methyl-CpG binding domain protein 1)

2003-02-01  

Identity

HGNC
LOCATION
18q21.1
LOCUSID
ALIAS
CXXC3,PCM1,RFT
FUSION GENES

Other Information

Locus ID:

NCBI: 4152
MIM: 156535
HGNC: 6916
Ensembl: ENSG00000141644

Variants:

dbSNP: 4152
ClinVar: 4152
TCGA: ENSG00000141644
COSMIC: MBD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141644ENST00000269468Q9UIS9
ENSG00000141644ENST00000269471Q9UIS9
ENSG00000141644ENST00000339998Q9UIS9
ENSG00000141644ENST00000347968Q9UIS9
ENSG00000141644ENST00000353909Q9UIS9
ENSG00000141644ENST00000382948Q9UIS9
ENSG00000141644ENST00000398488Q9UIS9
ENSG00000141644ENST00000398493Q9UIS9
ENSG00000141644ENST00000398495A0A0A0MS90
ENSG00000141644ENST00000457839Q9UIS9
ENSG00000141644ENST00000585595Q9UIS9
ENSG00000141644ENST00000585672Q9UIS9
ENSG00000141644ENST00000587605Q9UIS9
ENSG00000141644ENST00000588937Q9UIS9
ENSG00000141644ENST00000589541K7EN65
ENSG00000141644ENST00000589733K7EMA9
ENSG00000141644ENST00000590208Q9UIS9
ENSG00000141644ENST00000590215K7EIN3
ENSG00000141644ENST00000591416Q9UIS9
ENSG00000141644ENST00000591535Q9UIS9
ENSG00000141644ENST00000592060K7EPZ6

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127889252003Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation.97
127116032003Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.79
127706742003Identification of MeCP2 mutations in a series of females with autistic disorder.72
121243842002The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.70
156918492005Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins.49
167574752006Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation.38
213263582011MeCP2: structure and function.34
126655822003MCAF mediates MBD1-dependent transcriptional repression.33
257985782015SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation.33
164322382006The methyl-CpG binding protein MBD1 is required for PML-RARalpha function.30

Citation

Dessen P

MBD1 (methyl-CpG binding domain protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41308/mbd1