MKNK2 (MAPK interacting serine/threonine kinase 2)

2003-11-01  

Identity

HGNC
MKNK2
LOCATION
19p13.3
LOCUSID
2872
ALIAS
GPRK7,MNK2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2872
MIM: 605069
HGNC: 7111
Ensembl: ENSG00000099875

Variants:

dbSNP: 2872
ClinVar: 2872
TCGA: ENSG00000099875
COSMIC: MKNK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099875ENST00000250896Q9HBH9
ENSG00000099875ENST00000586828K7EK27
ENSG00000099875ENST00000588014K7EJ98
ENSG00000099875ENST00000589441K7EMP5
ENSG00000099875ENST00000589509K7ELN0
ENSG00000099875ENST00000589534K7ELG3
ENSG00000099875ENST00000591142Q9NV89
ENSG00000099875ENST00000591588K7EIN7
ENSG00000099875ENST00000591601Q9HBH9

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Insulin signaling pathwayKEGGko04910
MAPK signaling pathwayKEGGhsa04010
Insulin signaling pathwayKEGGhsa04910
HIF-1 signaling pathwayKEGGhsa04066

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367646012023MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion.3
367646012023MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion.3
321703392021Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis.9
335640732021MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.8
336023012021SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma.31
338363452021MKNK2 enhances chemoresistance of ovarian cancer by suppressing autophagy via miR-125b.6
321703392021Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis.9
335640732021MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.8
336023012021SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma.31
338363452021MKNK2 enhances chemoresistance of ovarian cancer by suppressing autophagy via miR-125b.6
303290872018Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment.33
303290872018Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment.33
288782912017MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer.14
288782912017MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer.14
266683152016Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.16

Citation

Dessen P

MKNK2 (MAPK interacting serine/threonine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41372/css/gene-explorer/js/web-card-gene.js