MMP1 (matrix metallopeptidase 1)

2003-02-01  

Identity

HGNC
LOCATION
11q22.2
LOCUSID
ALIAS
CLG,CLGN

Other Information

Locus ID:

NCBI: 4312
MIM: 120353
HGNC: 7155
Ensembl: ENSG00000196611

Variants:

dbSNP: 4312
ClinVar: 4312
TCGA: ENSG00000196611
COSMIC: MMP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196611ENST00000315274P03956

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
Bladder cancerKEGGko05219
PPAR signaling pathwayKEGGhsa03320
Pathways in cancerKEGGhsa05200
Bladder cancerKEGGhsa05219
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Collagen degradationREACTOMER-HSA-1442490
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

References

Pubmed IDYearTitleCitations
157078902005PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.250
174293932007Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.248
184475762008MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis.166
127068532003Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion.114
196087652009ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis.114
215191442011MMP-1 drives immunopathology in human tuberculosis and transgenic mice.99
193796982009Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site.90
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
179213242007IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation.79
212799942011Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation.76

Citation

Dessen P

MMP1 (matrix metallopeptidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41387/mmp1