MMP16 (matrix metallopeptidase 16)

2003-02-01  

Identity

HGNC
MMP16
LOCATION
8q21.3
LOCUSID
4325
ALIAS
C8orf57,MMP-X2,MT-MMP2,MT-MMP3,MT3-MMP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4325
MIM: 602262
HGNC: 7162
Ensembl: ENSG00000156103

Variants:

dbSNP: 4325
ClinVar: 4325
TCGA: ENSG00000156103
COSMIC: MMP16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156103ENST00000286614P51512
ENSG00000156103ENST00000522726E5RJA7

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361208332023MMP16 as NSCL ± P Susceptible Gene in Western Han Chinese.0
372446352023M1 macrophage-derived exosomes containing miR-150 inhibit glioma progression by targeting MMP16.0
361208332023MMP16 as NSCL ± P Susceptible Gene in Western Han Chinese.0
372446352023M1 macrophage-derived exosomes containing miR-150 inhibit glioma progression by targeting MMP16.0
350620572022Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC).5
350620572022Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC).5
332415322021Association between MMP16 rs60298754 and clinical phenotypes of Parkinson's disease in southern Chinese.1
344481152021microRNA-4429-5p suppresses the malignant development of colon cancer by targeting matrix metalloproteinase 16.0
344486442021LncRNA NEAT1 regulates MMP-16 by targeting miR-200a/b to aggravate inflammation in asthma.4
347473002021Circular RNA hsa_circ_0002360 promotes non-small cell lung cancer progression through upregulating matrix metalloproteinase 16 and sponging multiple micorRNAs.5
332415322021Association between MMP16 rs60298754 and clinical phenotypes of Parkinson's disease in southern Chinese.1
344481152021microRNA-4429-5p suppresses the malignant development of colon cancer by targeting matrix metalloproteinase 16.0
344486442021LncRNA NEAT1 regulates MMP-16 by targeting miR-200a/b to aggravate inflammation in asthma.4
347473002021Circular RNA hsa_circ_0002360 promotes non-small cell lung cancer progression through upregulating matrix metalloproteinase 16 and sponging multiple micorRNAs.5
321968112020A protective polymorphism in MMP16, improved blood gas levels, and chronic obstructive pulmonary diseases: Family and two population-based studies.2

Citation

Dessen P

MMP16 (matrix metallopeptidase 16)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41393/js/_common.js