MMP25 (matrix metallopeptidase 25)

2003-06-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
MMP-25,MMP20,MMP20A,MMPL1,MT-MMP
FUSION GENES

Other Information

Locus ID:

NCBI: 64386
MIM: 608482
HGNC: 14246
Ensembl: ENSG00000008516

Variants:

dbSNP: 64386
ClinVar: 64386
TCGA: ENSG00000008516
COSMIC: MMP25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008516ENST00000336577Q9NPA2
ENSG00000008516ENST00000612971O43923

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379860832023Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study.0
383104352023Elevated Plasma Levels of MT4-MMP and MT6-MMP; A New Observation in Patients with Thyroid Nodules.0
379860832023Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study.0
383104352023Elevated Plasma Levels of MT4-MMP and MT6-MMP; A New Observation in Patients with Thyroid Nodules.0
246690302014Expression of the matrix metalloproteases 2, 14, 24, and 25 and tissue inhibitor 3 as potential molecular markers in advanced human gastric cancer.14
246690302014Expression of the matrix metalloproteases 2, 14, 24, and 25 and tissue inhibitor 3 as potential molecular markers in advanced human gastric cancer.14
238516922013Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells.55
238516922013Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells.55
223671942012Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities.50
223671942012Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities.50
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
203080722010Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinase.16
203376482010Serum metalloproteinase leukolysin (MMP-25/MT-6): a potential metabolic marker for atopy-associated inflammation.0
205016112010MT6-MMP is present in lipid rafts and faces inward in living human PMNs but translocates to the cell surface during neutrophil apoptosis.7
205875462010Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.8

Citation

Dessen P

MMP25 (matrix metallopeptidase 25)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41402/haematological-explorer/js/js/_common.js