MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component)

2004-04-01  

Identity

HGNC
MMS19
LOCATION
10q24.1
LOCUSID
64210
ALIAS
CIAO4,MET18,MMS19L,hMMS19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64210
MIM: 614777
HGNC: 13824
Ensembl: ENSG00000155229

Variants:

dbSNP: 64210
ClinVar: 64210
TCGA: ENSG00000155229
COSMIC: MMS19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155229ENST00000327238Q96T76
ENSG00000155229ENST00000355839Q96T76
ENSG00000155229ENST00000370782Q96T76
ENSG00000155229ENST00000415383Q96T76
ENSG00000155229ENST00000422685B0QZ77
ENSG00000155229ENST00000434392H7C1W5
ENSG00000155229ENST00000434538H0Y746
ENSG00000155229ENST00000437002Q5T454
ENSG00000155229ENST00000438925Q96T76
ENSG00000155229ENST00000439048F8WCH8
ENSG00000155229ENST00000441194Q96T76
ENSG00000155229ENST00000444411H0Y7V3
ENSG00000155229ENST00000448660H7C0A9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Cytosolic iron-sulfur cluster assemblyREACTOMER-HSA-2564830

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372014392023The c-MYC transcription factor conduces to resistance to cisplatin by regulating MMS19 in bladder cancer cells.1
372014392023The c-MYC transcription factor conduces to resistance to cisplatin by regulating MMS19 in bladder cancer cells.1
326322772020Structural insights into Fe-S protein biogenesis by the CIA targeting complex.10
326322772020Structural insights into Fe-S protein biogenesis by the CIA targeting complex.10
290356932018MMS19 localizes to mitochondria and protects the mitochondrial genome from oxidative damage.3
290356932018MMS19 localizes to mitochondria and protects the mitochondrial genome from oxidative damage.3
272356252016Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.4
278022082016MMS19 as a potential predictive marker of adjuvant chemotherapy benefit in resected non-small cell lung cancer.3
272356252016Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.4
278022082016MMS19 as a potential predictive marker of adjuvant chemotherapy benefit in resected non-small cell lung cancer.3
258928742015Methyl-methanesulfonate sensitivity 19 expression is associated with metastasis and chemoradiotherapy response in esophageal cancer.6
258928742015Methyl-methanesulfonate sensitivity 19 expression is associated with metastasis and chemoradiotherapy response in esophageal cancer.6
235855632013IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.16
236322082013The role of single nucleotide polymorphisms of the ERCC1 and MMS19 genes in predicting platinum-sensitivity, progression-free and overall survival in advanced epithelial ovarian cancer.7
236793172013Single nucleotide polymorphisms in the NER pathway and clinical outcome of patients with bone malignant tumors.9

Citation

Dessen P

MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/41410/favicon/case-report-explorer/js/lib/popper.js