MPL (MPL proto-oncogene, thrombopoietin receptor)

2003-02-01  

Identity

HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
C-MPL,CD110,MPLV,THCYT2,THPOR,TPOR

Other Information

Locus ID:

NCBI: 4352
MIM: 159530
HGNC: 7217
Ensembl: ENSG00000117400

Variants:

dbSNP: 4352
ClinVar: 4352
TCGA: ENSG00000117400
COSMIC: MPL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117400ENST00000372470P40238
ENSG00000117400ENST00000413998Q5JUY5
ENSG00000117400ENST00000643351A0A2R8YE13

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Platelet Aggregation (Plug Formation)REACTOMER-HSA-76009

References

Pubmed IDYearTitleCitations
378837942024PF4 activates the c-Mpl-Jak2 pathway in platelets.2
379398322024Germline MPL mutations may be a rare cause of "triple-negative" thrombocytosis.0
378837942024PF4 activates the c-Mpl-Jak2 pathway in platelets.2
379398322024Germline MPL mutations may be a rare cause of "triple-negative" thrombocytosis.0
359244082023Clonal evolution in hereditary thrombocytosis with MPL T487A mutation.0
360314332023Novel modes of MPL activation in triple-negative myeloproliferative neoplasms.0
364760172023Frequency of JAK2V617F, MPL and CALR driver mutations and associated clinical characteristics in a Norwegian patient cohort with myeloproliferative neoplasms.0
373785672023MPL gene mutation is a possible risk factor for thrombosis in patients with essential thrombocythemia in Japan.1
374384902023Genomic and computational analysis of four novel variants of MPL gene in Congenital Amegakaryocytic Thrombocytopenia.0
376100302023A novel mutation in MECOM affects MPL regulation in vitro and results in thrombocytopenia and bone marrow failure.1
378838142023Assessment of intestinal status in MPL(W515L) mutant myeloproliferative neoplasms mice model.0
381115182023JAK2, CALR, and MPL Mutation Profiles in Colombian patients with BCR-ABL Negative Myeloproliferative Neoplasms.1
359244082023Clonal evolution in hereditary thrombocytosis with MPL T487A mutation.0
360314332023Novel modes of MPL activation in triple-negative myeloproliferative neoplasms.0
364760172023Frequency of JAK2V617F, MPL and CALR driver mutations and associated clinical characteristics in a Norwegian patient cohort with myeloproliferative neoplasms.0

Citation

Dessen P

MPL (MPL proto-oncogene, thrombopoietin receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41419/js/favicon/css/card-gene.css