MTA2 (metastasis associated 1 family member 2)

2003-02-01  

Identity

HGNC
LOCATION
11q12.3
LOCUSID
ALIAS
MTA1L1,PID
FUSION GENES

Other Information

Locus ID:

NCBI: 9219
MIM: 603947
HGNC: 7411
Ensembl: ENSG00000149480

Variants:

dbSNP: 9219
ClinVar: 9219
TCGA: ENSG00000149480
COSMIC: MTA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149480ENST00000278823O94776
ENSG00000149480ENST00000278823A0A024R534
ENSG00000149480ENST00000524902O94776
ENSG00000149480ENST00000527204O94776

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
110990472000Deacetylation of p53 modulates its effect on cell growth and apoptosis.245
121243842002The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.70
129201322003The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.51
270653262016Long non-coding RNA SNHG5 suppresses gastric cancer progression by trapping MTA2 in the cytosol.41
166450432006Metastasis-associated protein 2 is a repressor of estrogen receptor alpha whose overexpression leads to estrogen-independent growth of human breast cancer cells.24
240107372013MTA2 promotes gastric cancer cells invasion and is transcriptionally regulated by Sp1.18
253945322014Role of MTA2 in human cancer.16
225854292012Expression of metastasis-associated protein 2 (MTA2) might predict proliferation in non-small cell lung cancer.11
234007162013MTA2 expression is a novel prognostic marker for pancreatic ductal adenocarcinoma.10
249698342014Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression.10

Citation

Dessen P

MTA2 (metastasis associated 1 family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41444/mta2-(metastasis-associated-1-family-member-2)