NCAM2 (neural cell adhesion molecule 2)

2003-11-01  

Identity

HGNC
NCAM2
LOCATION
21q21.1
LOCUSID
4685
ALIAS
NCAM21
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4685
MIM: 602040
HGNC: 7657
Ensembl: ENSG00000154654

Variants:

dbSNP: 4685
ClinVar: 4685
TCGA: ENSG00000154654
COSMIC: NCAM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154654ENST00000284894H9KV31
ENSG00000154654ENST00000400546O15394

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Prion diseasesKEGGko05020
Prion diseasesKEGGhsa05020

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
209323102010Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study.46
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
266112612015Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.18
213002892011Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule.13
212146742011Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy.5
187069122008Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.3
200294092010Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.2
298958982018NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor.2
275966832016NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition?1

Citation

Dessen P

NCAM2 (neural cell adhesion molecule 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41504/ncam2