NCOR2 (nuclear receptor corepressor 2)

2003-05-01 Affiliation

Identity

HGNC

NCOR2

LOCATION

12q24.31

LOCUSID

9612

ALIAS

CTG26,N-CoR2,SMAP270,SMRT,SMRTE,SMRTE-tau,TNRC14,TRAC,TRAC-1,TRAC1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9612
MIM: 600848
HGNC: 7673
Ensembl: ENSG00000196498

Variants:

dbSNP: 9612
ClinVar: 9612
TCGA: ENSG00000196498
COSMIC: NCOR2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000196498	ENST00000356219	A0A384DVL6
ENSG00000196498	ENST00000404121	C9J7T7
ENSG00000196498	ENST00000404621	C9JE98
ENSG00000196498	ENST00000405201	Q9Y618
ENSG00000196498	ENST00000413172	H7C2R5
ENSG00000196498	ENST00000418829	H7BZU2
ENSG00000196498	ENST00000420698	C9J330
ENSG00000196498	ENST00000429285	C9J0Q5
ENSG00000196498	ENST00000440187	H7C0P3
ENSG00000196498	ENST00000440337	H7C184
ENSG00000196498	ENST00000448008	H7C1Y3
ENSG00000196498	ENST00000448614	C9JNV9
ENSG00000196498	ENST00000453428	H7C1J7
ENSG00000196498	ENST00000458234	C9JQE8
ENSG00000196498	ENST00000542927	H0YGK8

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Notch signaling pathway	KEGG	ko04330
Notch signaling pathway	KEGG	hsa04330
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by NOTCH1 in Cancer	REACTOME	R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer	REACTOME	R-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain Mutants	REACTOME	R-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	REACTOME	R-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	REACTOME	R-HSA-2894862
Signal Transduction	REACTOME	R-HSA-162582
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	REACTOME	R-HSA-2173793
Downregulation of SMAD2/3:SMAD4 transcriptional activity	REACTOME	R-HSA-2173795
Signaling by NOTCH	REACTOME	R-HSA-157118
Signaling by NOTCH1	REACTOME	R-HSA-1980143
NOTCH1 Intracellular Domain Regulates Transcription	REACTOME	R-HSA-2122947
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
Developmental Biology	REACTOME	R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation	REACTOME	R-HSA-381340
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
HDACs deacetylate histones	REACTOME	R-HSA-3214815

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22230954	2012	Structure of HDAC3 bound to co-repressor and inositol tetraphosphate.	149
14690607	2003	Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain.	90
21240272	2011	Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.	61
19730683	2009	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	59
16373395	2006	The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.	58
12441355	2003	Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT.	57
12840002	2003	A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation.	57
16453284	2006	Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women.	48
15300237	2004	Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells.	44
15802375	2005	Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT.	42

Citation

Dessen P

NCOR2 (nuclear receptor corepressor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41509/ncor2-(nuclear-receptor-corepressor-2)